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dc.contributor.advisorGranados, Carlos Eduardo
dc.contributor.advisorZubiría, Alberto de
dc.contributor.authorAulestia Baldeón, Elcie Carolina
dc.date.accessioned2013-12-16T17:54:36Z
dc.date.available2013-12-16T17:54:36Z
dc.date.created2013
dc.date.issued2013-12-16
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dc.identifier.urihttp://hdl.handle.net/10818/9372
dc.description60 Páginas.
dc.description.abstractEl Lupus Eritematoso Sistémico (LES) es un una enfermedad autoinmune con afectación multisistémica de gran variabilidad en su presentación y curso. Su diagnóstico se basa en características clínicas y de laboratorio en ausencia de otra enfermedad autoinmune que pueda explicar dichos hallazgos. Aunque el LES puede desarrollarse a cualquier edad, las mujeres en edad fértil son las principalmente afectadas. La relación mujer/hombre entre los 15 y 50 años de edad es > 8:1, mientras que llega a ser hasta 2:1 cuando ocurre durante la niñez o después de la menopausia. Esta prevalencia observada tanto en pacientes como en modelos animales, ha llevado a plantear la intervención de hormonas en el desarrollo y actividad de la misma. La relación entre el sistema neuroendocrino y el sistema inmune ha sido ampliamente demostrada. Comparten una red de conexiones mediadas por vías nerviosas, circuitos hormonales, interacciones celulares y humorales, así como una multitud de citoquinas, neuropéotidos y quemoquinas. De una interacción recíproca y modulada entre ambos sistemas depende el mantenimiento de la homeostasis. El desarrollo de una enfermedad multisistémica como el LES es el resultado del rompimiento de la misma. El LES se caracteriza por periodos de exacerbaciones y remisiones de la actividad de la enfermedad. Varios determinantes de este comportamiento han sido estudiados, sin que se haya esclarecido uno en especial; sin embargo, derivado de estudios observacionales de estados fisiológicos relacionados con aumento de actividad (por ejemplo, el embarazo) varios autores han demostrado la asociación con algunas hormonas. Entre las principales que han demostrado tener un efecto inmuno-modulador se encuentran el estrógeno y la prolactina.es_CO
dc.language.isospaes_CO
dc.publisherUniversidad de La Sabana
dc.sourceUniversidad de La Sabana
dc.sourceIntellectum Repositorio Universidad de La Sabana
dc.subjectProlatina -- Investigaciones
dc.subjectEstradiol
dc.subjectLupus eritematoso cutáneo -- Piel -- Enfermedades
dc.titlePerfil de prolactina y estradiol en una cohorte de mujeres colombianas con lupus eritematoso sistémicoes_CO
dc.typebachelorThesis
dc.publisher.programEspecialización en Medicina Interna
dc.publisher.departmentFacultad de Medicina
dc.identifier.local256511
dc.identifier.localTE06227
dc.type.localTesis de especialización
dc.type.hasVersionpublishedVersion
dc.rights.accessRightsopenAccess
dc.creator.degreeEspecialista en Medicina Interna


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