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Terpenos provenientes de octocorales y sus derivados sintéticos: aislamiento, identificación, actividad citotóxica y acoplamiento molecular con proteínas involucradas en el cáncer

dc.contributor.advisorTello Camacho, Edisson
dc.contributor.advisorCastellanos Castillo, Fabio
dc.contributor.authorHurtado Varela, Diana Ximena
dc.date.accessioned2019-11-26T20:01:22Z
dc.date.available2019-11-26T20:01:22Z
dc.date.issued2019-10-10
dc.identifier.urihttp://hdl.handle.net/10818/38353
dc.description95 páginases_CO
dc.description.abstractMuchos organismos marinos, como los octocorales, se han caracterizado por biosintetizar moléculas con potencial citotóxico, uno de ellos es la Plexaura homomalla, la cual produce un grupo de compuestos denominados prostaglandinas, sustancias capaces de inhibir la multiplicación celular. Debido a que el cáncer es un grupo extenso de enfermedades causadas por la multiplicación celular no regulada, y que durante el año 2018 la pérdida de vidas por esta enfermedad superó los 9.5 millones, se hace necesaria la búsqueda de tratamientos alternativos, como las terapias dirigidas, que consisten en analizar los cambios genéticos e identificar qué genes se encuentran alterados en cada paciente, para usar medicamentos que ataquen específicamente ese gen. Por esta razón, se han venido desarrollando diversos estudios que permiten entender y establecer la relación entre la estructura del ligando (metabolito) y algunas enzimas asociadas a diversas actividades biológicas, uno de estos estudios es el acoplamiento (“docking”) molecular, que permite realizar modelamiento computacional, para facilitar la predicción de las mejores orientaciones de unión del ligando con un blanco molecular.es_CO
dc.formatapplication/pdfes_CO
dc.language.isospaes_CO
dc.publisherUniversidad de La Sabanaes_CO
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.sourceUniversidad de La Sabana
dc.sourceIntellectum Repositorio Universidad de La Sabana
dc.subjectAlcionarioses_CO
dc.subjectMoléculases_CO
dc.subjectCánceres_CO
dc.subjectTerapéuticaes_CO
dc.titleTerpenos provenientes de octocorales y sus derivados sintéticos: aislamiento, identificación, actividad citotóxica y acoplamiento molecular con proteínas involucradas en el cánceres_CO
dc.typemasterThesises_CO
dc.publisher.programMaestría en Diseño y Gestión de Procesoses_CO
dc.publisher.departmentFacultad de Ingenieríaes_CO
dc.identifier.local275073
dc.identifier.localTE10421
dc.type.hasVersionpublishedVersiones_CO
dc.rights.accessRightsrestrictedAccesses_CO
dc.creator.degreeMagíster en Diseño y Gestión de Procesosfes_CO
dcterms.referencesAbd El-Karim, S. S., Anwar, M. M., Mohamed, N. A., Nasr, T., & Elseginy, S. A. (2015). Design, synthesis, biological evaluation and molecular docking studies of novel benzofuran-pyrazole derivatives as anticancer agents. Bioorganic Chemistry, 63, 1–12. https://doi.org/10.1016/j.bioorg.2015.08.006eng
dcterms.referencesAbdel-Magid, A. F. (2015). Allosteric Modulators: An Emerging Concept in Drug Discovery. ACS Medicinal Chemistry Letters, 6(2), 104–107. https://doi.org/10.1021/ml5005365eng
dcterms.referencesAbdelhafez, O. M., Ahmed, E. Y., Abdel Latif, N. A., Arafa, R. K., Abd Elmageed, Z. Y., & Ali, H. I. (2019). Design and molecular modeling of novel P38α MAPK inhibitors targeting breast cancer, synthesized from oxygen heterocyclic natural compounds. Bioorganic and Medicinal Chemistry, 27(7), 1308–1319. https://doi.org/10.1016/j.bmc.2019.02.027eng
dcterms.referencesAgarwal, S., & Mehrotra, R. (2016). An overview of Molecular Docking. JSM Chem, 4(2), 1024.eng
dcterms.referencesAl-Awadhi, F. H., Salvador, L. A., Law, B. K., Paul, V. J., & Luesch, H. (2017). Kempopeptin C, a novel marine-derived serine protease inhibitor targeting invasive breast cancer. Marine Drugs, 15(9), 1–17. https://doi.org/10.3390/md15090290eng
dcterms.referencesAmin, K. M., Syam, Y. M., Anwar, M. M., Ali, H. I., Abdel-Ghani, T. M., & Serry, A. M. (2017). Synthesis and molecular docking studies of new furochromone derivatives as p38α MAPK inhibitors targeting human breast cancer MCF-7 cells. Bioorganic and Medicinal Chemistry, 25(8), 2423–2436. https://doi.org/10.1016/j.bmc.2017.02.065eng
dcterms.referencesAmin, K. M., Syam, Y. M., Anwar, M. M., Ali, H. I., Abdel-Ghani, T. M., & Serry, A. M. (2018). Synthesis and molecular docking study of new benzofuran and furo[3,2-g]chromone-based cytotoxic agents against breast cancer and p38α MAP kinase inhibitors. Bioorganic Chemistry. https://doi.org/10.1016/j.bioorg.2017.12.029eng
dcterms.referencesArdila, E., Sánchez, R., & Echeverry, J. (2001). Fases del desarrollo de un nuevo fármaco. In El manual moderno (Ed.), Estrategias de investigación en medicina clínica (pp. 123–134). Bogotá.spa
dcterms.referencesAsif, M., Al-Mansoub, M. A., Khan, M. S. S., Yehya, A. H. S., Ezzat, M. O., Oon, C. E., … Abdul Majid, A. M. S. (2017). Molecular mechanisms responsible for programmed cell death-inducing attributes of terpenes from Mesua ferrea stem bark towards human colorectal carcinoma HCT 116 cells. Journal of Applied Biomedicine, 15(1), 71–80. https://doi.org/10.1016/j.jab.2016.10.003eng
dcterms.referencesATCC. (2017a). A549 (ATCC® CCL-185TM). Retrieved from https://www.atcc.org/Products/All/CCL-185.aspxeng
dcterms.referencesATCC. (2017b). MDA-MB-231 (ATCC® HTB-26TM). Retrieved from https://www.atcc.org/Products/All/HTB-26.aspxeng
dcterms.referencesBauer Estrada, K. (2017). Aislamiento e identificación de compuestos con actividad citotóxica a partir de octocorales del caribe colombiano. Universidad de La 87 Sabanaspa
dcterms.referencesBlunt, J. W., Copp, B. R., Keyzers, R. A., Munro, M. H. G., & Prinsep, M. R. (2017). Marine natural products. Nat. Prod. Rep., 33, 382–431. https://doi.org/10.1039/C6NP00124Feng
dcterms.referencesChanbner, B. A., Lynch Jr, T. J., & Longo, D. L. (2009). Manual de oncología. (McGraw Hill, Ed.). Mexico, D.Fspa
dcterms.referencesChen, W. T., Yao, L. G., Li, X. W., & Guo, Y. W. (2015). Sarcophytrols A-C, new capnosane diterpenoids from the South China Sea soft coral Sarcophyton trocheliophorum. Tetrahedron Letters, 56, 1348–1352. https://doi.org/10.1016/j.tetlet.2015.01.157eng
dcterms.referencesChien, C. M., Yang, J. C., Wu, P. H., Wu, C. Y., Chen, G. Y., Wu, Y. C., … Chiu, C. C. (2019). Phytochemical naphtho[1,2-b] furan-4,5‑dione induced topoisomerase II-mediated DNA damage response in human non-small-cell lung cancer. Phytomedicine, 54, 109–119. https://doi.org/10.1016/j.phymed.2018.06.025eng
dcterms.referencesChrobak, E., Kadela-Tomanek, M., Bębenek, E., Marciniec, K., Wietrzyk, J., Trynda, J., … Boryczka, S. (2019). New phosphate derivatives of betulin as anticancer agents: Synthesis, crystal structure, and molecular docking study. Bioorganic Chemistry, 87, 613–628. https://doi.org/10.1016/j.bioorg.2019.03.060eng
dcterms.referencesCicenas, J., Zalyte, E., Rimkus, A., Dapkus, D., Noreika, R., & Urbonavicius, S. (2018, January 1). JNK, p38, ERK, and SGK1 inhibitors in cancer. Cancers. MDPI AG. https://doi.org/10.3390/cancers10010001eng
dcterms.referencesCuenta de Alto Costo. (2017). Situación del cancer 2017. Cuenta de alto costo. Bogotá.spa
dcterms.referencesDar, A. M., & Mir, S. (2017). Molecular Docking: Approaches, Types, Applications and Basic Challenges. Journal of Analytical & Bioanalytical Techniques, 08(02), 8–10. https://doi.org/10.4172/2155-9872.1000356eng
dcterms.referencesDavis, G. D. J., & Vasanthi, A. H. R. (2015). QSAR based docking studies of marine algal anticancer compounds as inhibitors of protein kinase B (PKBb). European Journal of Pharmaceutical Sciences, 30(76), 110–118. https://doi.org/10.1016/j.ejps.2015.04.026eng
dcterms.referencesEbrahim, H. Y., Mohyeldin, M. M., Hailat, M. M., & El Sayed, K. A. (2016). (1S,2E,4S,7E,11E)-2,7,11-Cembratriene-4,6-diol semisynthetic analogs as novel c-Met inhibitors for the control of c-Met-dependent breast malignancies. Bioorganic and Medicinal Chemistry, 24, 5748–5761. https://doi.org/10.1016/j.bmc.2016.09.032eng
dcterms.referencesElhassanny, A. E. M., Ladin, D. A., Soliman, E., Albassam, H., Morris, A., Kobet, R., … Van Dross, R. (2019). Prostaglandin D 2 -ethanolamide induces skin cancer apoptosis by suppressing the activity of cellular antioxidants. Prostaglandins and Other Lipid Mediators, 142, 9–23. https://doi.org/10.1016/j.prostaglandins.2019.03.001eng
dcterms.referencesFani, N., Bordbar, A. K., Ghayeb, Y., Sepehri, & S., Sepehri, S., & Sarma, R. H. (2014). Computational design of Tryprostatin-A derivatives as novel αβ-tubulin inhibitors Computational design of Tryprostatin-A derivatives as novel αβtubulin inhibitors. Journal of Biomolecular Structure and Dynamics, 33, 471– 88 486. https://doi.org/10.1080/07391102.2014.892028eng
dcterms.referencesFattorusso, E., Gerwick, W. H., & Taglialatela-Scafati, O. (2012). Handbook of Marine Natural Products. (Springer, Ed.), Springer. New York: Springer Netherlands. https://doi.org/10.1007/978-90-481-3834-0eng
dcterms.referencesGranados García, M., Arrieta Rodríguez, O. G., & Hinojosa Gómez, J. (2016). Tratamiento del cancer: Oncología médica, quirúrgica y radioterapia. (E. manual Moderno, Ed.) (1ra Edició). Mexico, D.Fspa
dcterms.referencesGranados García, M., & Herrera Gómez, A. (2010). Manual de Oncologia. (McGraw Hill, Ed.) (Cuarta). Mexico, D.F.spa
dcterms.referencesGutiérrez, J. (2006). Blancos moleculares. Rev. Med. Clin. Condes, 17(2), 44–48. Hegazy, M.-E. F., Elshamy, A. I., Mohamed, T. A., Hamed, A. R., A Ibrahim, M. A., Ohta, S., & Paré, P. W. (2017). Cembrene Diterpenoids with Ether Linkages from Sarcophyton ehrenbergi: An Anti-Proliferation and Molecular-Docking Assessment. Marine Drugs, 15, 192. https://doi.org/10.3390/md15060192eng
dcterms.referencesHsiao, K., Zegzouti, H., Vidugiriene, J., & Goueli, S. A. (2002). p38α Kinase Assay. Promega Corporation, (Vol. 295). Madison, USA. Retrieved from www.promega.com/tbs/tm313/tm313.htmleng
dcterms.referencesHsiao, T. H., Sung, C. S., Lan, Y. H., Wang, Y. C., Lu, M. C., Wen, Z. H., … Sung, P. J. (2015). New anti-inflammatory cembranes from the cultured soft coral Nephthea columnaris. Marine Drugs, 13, 3443–3453. https://doi.org/10.3390/md13063443eng
dcterms.referencesHuang, X. C., Xiao, X., Zhang, Y. K., Talele, T. T., Salim, A. A., Chen, Z. S., & Capon, R. J. (2014). Lamellarin O, a pyrrole alkaloid from an Australian marine sponge, Ianthella sp., reverses BCRP mediated drug resistance in cancer cells. Marine Drugs, 12, 3818–3837. https://doi.org/10.3390/md12073818eng
dcterms.referencesInstituto Nacional del Cáncer. (2014). Terapias dirigidas contra el cancer. Retrieved 1 March 2017, from https://www.cancer.gov/espanol/cancer/tratamiento/tipos/terapia-dirigida/hojainformativa-terapias-dirigidasspa
dcterms.referencesInstituto Nacional del Cáncer. (2015). Naturaleza del cancer ¿Qué es el cáncer? Retrieved 7 September 2017, from https://www.cancer.gov/espanol/cancer/naturaleza/que-esspa
dcterms.referencesInternational Agency for Research on Cancer. (2018). Global Cancer Observatory. Retrieved 15 September 2018, from http://gco.iarc.fr/eng
dcterms.referencesInternational Agency for Research on Cancer. (2019). Global Cancer Observatory. Retrieved 19 May 2019, from https://gco.iarc.fr/eng
dcterms.referencesJack, A., & Kau, Y. (2008). PI 0807737-1 A2. Republica Federativa de Brasil.spa
dcterms.referencesJaqueline, A., Zúñiga, P., & Rojo Domínguez, A. (2002). Simulación del reconocimiento entre proteínas y moléculas orgánicas o docking. Aplicación al diseño de fármacos. Depto Bioquímica Universidad Nacional Autónoma de México. Cd Universitaria, 26, 129–145. Retrieved from http://laguna.fmedic.unam.mx/mensajebioquimicospa
dcterms.referencesJemimah Naine, S., Subathra Devi, C., Mohanasrinivasan, V., George Priya Doss, C., & Thirumal Kumar, D. (2015). Binding and molecular dynamic studies of sesquiterpenes (2R-acetoxymethyl-1,3,3-trimethyl-4t-(3-methyl-2-buten-1-yl)- 89 1t- cyclohexanol) derived from marine Streptomyces sp. VITJS8 as potential anticancer agent. Applied Microbiology and Biotechnology, 100, 2869–2882. https://doi.org/10.1007/s00253-015-7156-2spa
dcterms.referencesKavitha, T., & Velraj, G. (2018). Molecular structure, spectroscopic and docking analysis of 1,3-diphenylpyrazole-4-propionic acid: A good prostaglandin reductase inhibitor. Journal of Molecular Structure, 1155, 819–830. https://doi.org/10.1016/j.molstruc.2017.11.031eng
dcterms.referencesKe, X., & Shen, L. (2017). Molecular targeted therapy of cancer: The progress and future prospect. Frontiers in Laboratory Medicine. https://doi.org/10.1016/j.flm.2017.06.001eng
dcterms.referencesKittakoop, P. (2015). Anticancer drugs and potential anticancer leads inspired by natural products. In Studies in Natural Products Chemistry (pp. 251–307). https://doi.org/10.1016/B978-0-444-63460-3.00005-5eng
dcterms.referencesKukol, A. (2015). Molecular Modeling of Proteins. (Springer Protocols, Ed.) (Second). Hertfordshire, UK. https://doi.org/10.1007/978-1-59745-177-2eng
dcterms.referencesLadin, D. A., Soliman, E., Escobedo, R., Fitzgerald, T. L., Yang, L. V., Burns, C., & Van Dross, R. (2017). Synthesis and Evaluation of the Novel Prostamide, 15- Deoxy, Δ 12,14 -Prostamide J 2 , as a Selective Antitumor Therapeutic . Molecular Cancer Therapeutics, 16(5), 838–849. https://doi.org/10.1158/1535- 7163.mct-16-0484eng
dcterms.referencesManda, S., Sharma, S., Wani, A., Joshi, P., Kumar, V., Guru, S. K., … Bharate, S. B. (2016). Discovery of a marine-derived bis-indole alkaloid fascaplysin, as a new class of potent P-glycoprotein inducer and establishment of its structureactivity relationship. European Journal of Medicinal Chemistry, 107, 1–11. https://doi.org/10.1016/j.ejmech.2015.10.049eng
dcterms.referencesMedina-Franco, J. L., Lopez-Vallejo, F., & Castillo, R. (2006). Diseño de farmacos asistidos por computadora. Educación Química, 17, 452–457.spa
dcterms.referencesMohyeldin, M. M., Akl, M. R., Siddique, A. B., Hassan, H. M., & El Sayed, K. A. (2017). The marine-derived pachycladin diterpenoids as novel inhibitors of wildtype and mutant EGFR. Biochemical Pharmacology, 126, 51–68. https://doi.org/10.1016/j.bcp.2016.12.003eng
dcterms.referencesMosmann, T. (1983). Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays. Journal of Immunological Methods, 65, 55–63. https://doi.org/10.1016/0022-1759(83)90303-4eng
dcterms.referencesMukesh, B., & Rakesh, K. (2011). Molecular Docking: A Review. International Journal of Research in Ayurveda & Pharmacy, 2(6), 1746–1751eng
dcterms.referencesMurahari, M., Kharkar, P. S., Lonikar, N., Yc, M., & Mayur, Y. (2017). Design, synthesis, biological evaluation, molecular docking and QSAR studies of 2,4- dimethylacridones as anticancer agents. European Journal of Medicinal Chemistry, 130, 154–170. https://doi.org/10.1016/j.ejmech.2017.02.022eng
dcterms.referencesNel, M., Joubert, A. M., Dohle, W., Potter, B. V. L., & Theron, A. E. (2018). Modes of cell death induced by tetrahydroisoquinoline-based analogs in MDA-MB-231 breast and A549 lung cancer cell lines. Drug Design, Development and Therapy, 12, 1881–1904. https://doi.org/10.2147/DDDT.S152718eng
dcterms.referencesNewman, D. J., & Cragg, G. M. (2014). Marine-sourced anti-cancer and cancer pain 90 control agents in clinical and late preclinical development. Marine Drugs. https://doi.org/10.3390/md12010255eng
dcterms.referencesNitiss, J. L. (2009, May). Targeting DNA topoisomerase II in cancer chemotherapy. Nature Reviews Cancer. https://doi.org/10.1038/nrc2607eng
dcterms.referencesOtero Ramón, P. F. (2016). Situación del Cáncer en la población aduta atendida en el SGSSS de Colombia. Bogotá.spa
dcterms.referencesParker, J. (1995). Prostaglandin A, Protein Interactions and Inhibition of Cellular Proliferation. Prostaglandins, 50, 359–375. https://doi.org/0090- 6980(95)00136-0eng
dcterms.referencesPeña Diaz, A., Arroyo Begovich, A., Gomez Puyou, A., & Tapia, R. (2004). Bioquímica. (Limusa, Ed.) (Primera Ed). México D.F.spa
dcterms.referencesPromega Corporation. (2018). Using the Kinase Enzyme Systems with the ADPGloTM Assay. Madison, USA. Retrieved from www.promega.comeng
dcterms.referencesReina Gamba, L. E. (2011). Estudio de bioprospección de octocorales de los géneros Eunicea y Plexaura del caribe colombiano, como fuente de metabolitos con actividad antiinflamatoria. Universidad Nacional de Colombia.spa
dcterms.referencesRuddon, R. W. (2007). Cancer Biology. (Oxford University, Ed.) (Fourth). Michigan.eng
dcterms.referencesRuiz-Torres, V., Encinar, J. A., Herranz-López, M., Pérez-Sánchez, A., Galiano, V., Barrajón-Catalán, E., & Micol, V. (2017). An Updated Review on Marine Anticancer Compounds: The Use of Virtual Screening for the Discovery of Small-Molecule Cancer Drugs. Molecules, 22, 1037. https://doi.org/10.3390/molecules22071037eng
dcterms.referencesSankara Rao, N., Nagesh, N., Lakshma Nayak, V., Sunkari, S., Tokala, R., Kiranmai, G., … Kamal, A. (2019). Design and synthesis of DNA-intercalative naphthalimide-benzothiazole/cinnamide derivatives: cytotoxicity evaluation and topoisomerase-IIα inhibition. MedChemComm, 10(1), 72–79. https://doi.org/10.1039/c8md00395eeng
dcterms.referencesSarmiento-Vizcaíno, A., Braña, A., Pérez-Victoria, I., Martín, J., de Pedro, N., Cruz, M., … Blanco, G. (2017). Paulomycin G, a New Natural Product with Cytotoxic Activity against Tumor Cell Lines Produced by Deep-Sea Sediment Derived Micromonospora matsumotoense M-412 from the Avilés Canyon in the Cantabrian Sea. Marine Drugs. https://doi.org/10.3390/md15090271eng
dcterms.referencesSchwab, M. (2001). Encyclopedic Reference of Cancer. (Springer, Ed.). Germany.eng
dcterms.referencesSebaugh, J. L. (2011). Guidelines for accurate EC50/IC50 estimation. Pharmaceutical Statistics, 10(2), 128–134. https://doi.org/10.1002/pst.426eng
dcterms.referencesSen, B., & Johnson, F. M. (2011). Regulation of Src Family Kinases in Human Cancers. Journal of Signal Transduction, 2011, 1–14. https://doi.org/10.1155/2011/865819eng
dcterms.referencesShi, W., Marcus, S. L., & Lowary, T. L. (2011). Cytotoxicity and topoisomerase I/II inhibition of glycosylated 2-phenyl-indoles, 2-phenyl-benzo[b]thiophenes and 2- phenyl-benzo[b]furans. Bioorganic and Medicinal Chemistry, 19, 603–612. https://doi.org/10.1016/j.bmc.2010.10.054eng
dcterms.referencesTa-Yuan, W., Hong-Chieh, T., Yin Di, S., Tsong-Long, H., & Ping Jyun, S. (2017). Sterols from the Octocoral Nephthea columnaris. Marine Drugs, 15, 212. https://doi.org/10.3390/md15070212eng
dcterms.referencesTello, E., Castellanos, L., Arevalo-Ferro, C., & Duque, C. (2009). Cembranoid diterpenes from the Caribbean sea whip Eunicea knighti. Journal of Natural Products. https://doi.org/10.1021/np9002492eng
dcterms.referencesTello, E., Castellanos, L., & Duque, C. (2013). Synthesis of cembranoid analogues and evaluation of their potential as quorum sensing inhibitors. Bioorganic and Medicinal Chemistry. https://doi.org/10.1016/j.bmc.2012.10.022eng
dcterms.referencesTopoGEN Inc. (2011). Topoisomerase II Assay Kit User Manual. Florida, USAeng
dcterms.referencesUsha, T., Kumar Middha, S., Goyal, A. K., Karthik, M., Manoj, D., Faizan, S., … Pande, V. (2014). Molecular docking studies of anti-cancerous candidates in Hippophae rhamnoides and Hippophae salicifolia. The Journal of Biomedical Research, 28(5), 406–415. https://doi.org/10.7555/JBR.28.20130110eng
dcterms.referencesWeaver, C. H. (2018). Precision Cancer Medicine: The Future of Cancer Treatment is Now. Retrieved 16 June 2019, from https://news.cancerconnect.com/treatment-care/precision-cancer-medicinethe-future-of-cancer-treatment-is-now-TBvsqWHdcUq92k-qhKUUJg/eng
dcterms.referencesWheeler, D. L., Iida, M., & Dunn, E. F. (2009). The Role of Src in Solid Tumors. The Oncologist, 14(7), 667–678. https://doi.org/10.1634/theoncologist.2009-0009eng
dcterms.referencesWilliam, G. (2003). Deep Water Octocorals. Retrieved 13 September 2017, from http://oceanexplorer.noaa.gov/explorations/03mountains/background/octocoral s/octocorals.htmleng
dcterms.referencesWorld Health Organization. (2016). Global Health Estimates 2015: Deaths by Cause, Age, Sex, by Country and by Region, 2000-2015. Retrieved from http://www.who.int/healthinfo/global_burden_disease/estimates/en/index1.htmleng
dcterms.referencesWorld Health Organization. (2017). Global Health Estimates (GHE). Retrieved 19 May 2019, from http://www.who.int/healthinfo/global_burden_disease/en/eng
dcterms.referencesWorzella, T., Butzler, M., Hennek, J., Hanson, S., Simdon, L., Goueli, S., … Zegzouti, H. (2017). A Flexible Workflow for Automated Bioluminescent Kinase Selectivity Profiling. SLAS Technology, 22(2), 153–162. https://doi.org/10.1177/2211068216677248eng
dcterms.referencesYin Di, S., Tzu-Rong, S., Zhi Hong, W., Tsong-Long, H., Lee-Shing, F., Jih-Jung, C., … Ping Jyun, S. (2015). Briarenolides K and L, New Anti-Inflammatory Briarane Diterpenoids from an Octocoral Briareum sp. (Briareidae). Marine Drugs, 13, 1037–1050. https://doi.org/10.3390/md13021037eng
dcterms.referencesZegzouti, H., Alves, J., Worzella, T., Vidugiris, G., Cameron, G., Vidugiriene, J., & Goueli, S. (2011). Screening and Profiling Kinase Inhibitors with a Luminescent ADP Detection Platform. Retrieved 22 May 2019, from https://worldwide.promega.com/resources/pubhub/screening-and-profilingkinase-inhibitors-with-a-luminescent-adp-detection-platform/eng
dcterms.referencesZhang, S., & Yu, D. (2012, March). Targeting Src family kinases in anti-cancer therapies: Turning promise into triumph. Trends in Pharmacological Sciences. https://doi.org/10.1016/j.tips.2011.11.002eng


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