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Identificación y caracterización de la proteína del cuello de las roptrias 5 (RON5) en Plasmodium falciparum y determinación de las regiones de unión a glóbulos rojos humanos

dc.contributor.advisorPatarroyo Gutiérrez, Manuel Alfonso
dc.contributor.authorCurtidor Castellanos, Hernando
dc.date.accessioned4/5/2016 9:10
dc.date.available4/5/2016 9:10
dc.date.issued2014-03-14
dc.identifier.urihttp://hdl.handle.net/10818/22983
dc.description87 páginases_CO
dc.description.abstractIn this research, advanced control strategies were designed under the Active Disturbance Rejection Control (ADRC) approach to increase the biomass production in microalgae cultures. For the above, from a control frame of reference, the development was envisaged into two stages, control and optimization. The first stage resulted in three different controllers designs: two ADRC strategies assisted by observer and a Model-Free Control (MFC). In each case, the aim was to guarantee the tracking of the reference signal. In the second stage, the design of two optimization strategies were achieves to increase the biomass production, offline and on-line. Comparing, at a simulation level, these strategies with other existing proposals, the following was found: 1) the ADRC strategies assisted by observer had a few dependence on the model, letting us to work with an approximate model that only required knowing of the system order and the input gain; 2) the off-line optimization, despite maximizing the biomass production, required knowing the model and 3) the proposal that combines MFC with on-line optimization, may act on any microalgae culture since it does not need a model. All the proposals are robust front to disturbances and variation of parameters allowing to increase the biomass production when an optimization strategy is used.en
dc.description.abstractLa malaria es una de las enfermedades infecciosas más prevalentes y mortales a nivel mundial. Cinco especies de Plasmodium (protozoario intracelular obligado del filo Apicomplexa) infectan al humano, siendo Plasmodium falciparum la especie responsable de las manifestaciones clínicas más severas, con amplia distribución en las zonas tropicales y subtropicales del África Subsahariana. Según los estimados de la Organización Mundial de la Salud (OMS), en el año 2010 se presentaron alrededor de 216 millones de casos de malaria y cerca de un millón de muertes, principalmente de niños menores de 5 años. Esta cifra se ha incrementado en los últimos años, luego de la aparición de variantes del parásito que son resistentes a drogas antimaláricas y por la resistencia a los insectidas por parte del mosquito. Es por lo tanto urgente el desarrollo de medidas de control efectivas que permitan la erradicación de esta parasitosis.es_CO
dc.formatapplication/pdfes_CO
dc.language.isospaes_CO
dc.publisherUniversidad de La Sabanaes_CO
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.sourceUniversidad de La Sabana
dc.sourceIntellectum Repositorio Universidad de La Sabana
dc.subjectEritrocitoses_CO
dc.subjectMalaria -- Colombiaes_CO
dc.subjectPlasmodium -- Malariaes_CO
dc.subjectProteínas de la sangre -- Malariaes_CO
dc.subjectParásitos -- Malariaes_CO
dc.subjectMedicamentos -- Malariaes_CO
dc.subjectMosquitos -- Erradicación -- Malariaes_CO
dc.titleIdentificación y caracterización de la proteína del cuello de las roptrias 5 (RON5) en Plasmodium falciparum y determinación de las regiones de unión a glóbulos rojos humanoses_CO
dc.typedoctoral thesises_CO
dc.identifier.local259158
dc.identifier.localTE06382
dc.type.hasVersionpublishedVersiones_CO
dc.rights.accessRightsopenAccesses_CO
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thesis.degree.disciplineFacultad de Ingenieríaes_CO
thesis.degree.levelDoctorado en Biocienciases_CO
thesis.degree.nameDoctor en Biocienciases_CO


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