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dc.contributor.advisorDiaz Quijano, Diana Marcela
dc.contributor.authorMoreno Giraldo, Angelica María
dc.contributor.authorBastidas Goye, Alirio Rodrigo
dc.date.accessioned2023-03-09T21:26:01Z
dc.date.available2023-03-09T21:26:01Z
dc.date.issued2021-11-05
dc.identifier.urihttp://hdl.handle.net/10818/54319
dc.description27 páginases_CO
dc.description.abstractBackground and Objective Chronic Obstructive Pulmonary Disease (COPD) is diagnosed using the FEV1/FVC, which has limitations as a diagnostic test. We assessed the validity of several measures derived from the expiratory phase of the flow-volume curve obtained from spirometry to diagnose COPD: the slopes corresponding to the volume expired after the 50% and 75% of the FVC, the slope formed between the Peak Expiratory Flow (PEF) and the FVC, and the area under the expiratory flow/volume curve. Methods We conducted a cross-sectional diagnostic test study in 765 consecutive patients referred to spirometry because of respiratory symptoms. We compared the reproducibility and accuracy of the proposed measures against FEV1/FVC post-bronchodilator <0.70. We evaluated the proportion of respiratory symptoms for both the FEV1/FVC and FEV1/FEV6 ratios, and the PEF slope. Results Subjects had a mean age of 65.8, 57% were women, and 35% had COPD. The test-retest intraclass correlation coefficient for FEV1/FVC was 0.89, it was 0.85 for FEV1/FV6 was, for the PEF slope was 0.83, for the area under the expiratory flow/volume curve was 0.93, for the area under the potential expiratory flow/volume curve was 0.96, for the area under the potential expiratory flow/volume of at 75% of the FVC 0.97, and for the slope at 50% of the FVC was 0.82. The area under-the-ROC curve was 0.99 for FEV1/ FEV6, 0.99 for the slope at 50% of the FVC, and 0.98 for the PEF slope.en
dc.formatapplication/pdfes_CO
dc.language.isoenges_CO
dc.publisherUniversidad de La Sabanaes_CO
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.sourceUniversidad de La Sabana
dc.sourceIntellectum Repositorio Universidad de La Sabana
dc.titleComparison of new spirometry measures to diagnose Chronic Obstructive Pulmonary Disease : A diagnostic test studyes_CO
dc.typemaster thesises_CO
dc.identifier.local291516
dc.identifier.localTE12191
dc.type.hasVersionpublishedVersiones_CO
dc.rights.accessRightsrestrictedAccesses_CO
dc.subject.armarcEspirometría
dc.subject.armarcEnfermedad cardiopulmonar
dc.subject.armarcBronquitis
dc.subject.decsDiagnóstico precoz
dc.subject.decsCurva ROC
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thesis.degree.disciplineFacultad de Medicinaes_CO
thesis.degree.levelMaestría en Epidemiologíaes_CO
thesis.degree.nameMagíster en Epidemiologíaes_CO


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