Mostrar el registro sencillo del ítem

dc.contributor.authorFernandez-Sarmiento, Jaime
dc.contributor.authorCorrale, Catalina
dc.contributor.authorObando, Evelyn
dc.contributor.authorAmin, Jennifer
dc.contributor.authorBastidas Goyes, Alirio
dc.contributor.authorBarrera Lopez, Pedro A.
dc.contributor.authorBernal Ortiz , Nicolas
dc.date.accessioned2023-02-27T15:49:13Z
dc.date.available2023-02-27T15:49:13Z
dc.date.issued2021
dc.identifier.citationHernandez-Sarmiento J, Corrales S C , Obando E, Amin J, Bastidas Goyes A , et al. (2021) Factors Associated with Severe Acute Respiratory Infections Due to Rhinovirus/Enterovirus Complex in Children and Their Comparison with Those of Respiratory Syncytial Virus. Arch Pediatr Infect Dis.In Press(In Press):e115548. doi: 10.5812/pedinfect.115548.es_CO
dc.identifier.issn23221836
dc.identifier.otherhttps://brieflands.com/articles/apid-115548.html
dc.identifier.urihttp://hdl.handle.net/10818/54181
dc.description10 páginas
dc.description.abstractBackground: Acute respiratory tract infections (ARTIs) are one of the main causes of morbidity and mortality in children under the age of five worldwide. Objectives: The objective of this research was to describe the main characteristics of hospitalized patients with ARTI caused by the rhinovirus/enterovirus (RV/EV) complex and the risk factors associated with severe infection. Methods: This was a retrospective descriptive study in patients from one month to 18-years-old who had been hospitalized for ARTI between October 2015 and December 2019 at Fundación Cardioinfantil in Bogotá, Colombia, and had had an RT-PCR viral panel during their hospitalization. Rhinovirus/enterovirus infection was characterized to identify factors associated with disease severity as compared to respiratory syncytial virus (RSV). A multivariate analysis was performed, controlling for confounding factors, to identify groups at risk of developing associated acute respiratory distress syndrome (ARDS). Results: During the study period, 645 RT-PCRs were performed, with the twomain etiological agents identified being RV/EV (n = 224) and RSV (n = 68). Themedian age of patients with the RV/EV complex was 27months (IQR: 8 - 70), and sevenmonths for those with RSV (IQR: 2 - 11). Severe RV/EV complex infections required more transfers to intensive care (47% vs. 11%), showed more viral coinfection (OR: 2.13, 95% CI: 1.42 - 4.64), and had less bacterial coinfection (OR: 0.55, 95% CI: 0.31 - 0.98) than RSV infections. The RV/EV group had a higher risk of developing ARDS (OR: 3.6, 95% CI: 1.07 - 12:18), especially in premature infants (P: 0.05; exp(B), 2.99; 95% CI = 1.01 - 8.82), those with heart disease (P: 0.047; exp(B), 2.99; 95% CI = 1.01 - 8.82), and those with inborn errors of metabolism (P: 0.032; exp(B), 5 - 01; 95% CI = 1.15 - 21.81). A total of 13 patients from both study groups died (4.5%), with no differences found between the groups (RV/EV 54% vs. RSV 46%; P = 0.3). Conclusions: Respiratory infection due to RV/EV in children can frequently be severe, requiring management with intensive care therapy. When compared to RSV, this complex is more frequently associated with the development of ARDS, especially in risk groups such as those with prematurity, heart disease, or inborn errors of metabolism.en
dc.language.isoenges_CO
dc.publisherArch Pediatr Infect Dis.In Press(In Press):es_CO
dc.relation.ispartofseriesArch Pediatr Infect Dis.In Press(In Press):e115548
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.sourceUniversidad de La Sabanaes_CO
dc.sourceIntellectum Repositorio Universidad de La Sabanaes_CO
dc.subject.otherViral Infectionen
dc.subject.otherEnterovirusen
dc.subject.otherRhinovirusen
dc.subject.otherChildrenen
dc.subject.otherARDSen
dc.subject.otherPneumoniaen
dc.subject.otherRespiratory tract Infectionsen
dc.subject.otherRespiratory syncytial virusen
dc.titleFactors Associated with Severe Acute Respiratory Infections Due to Rhinovirus/Enterovirus Complex in Children and Their Comparison with Those of Respiratory Syncytial Virusen
dc.typejournal articlees_CO
dc.type.hasVersionpublishedVersiones_CO
dc.rights.accessRightsopenAccesses_CO
dc.identifier.doi10.5812/pedinfect.115548


Ficheros en el ítem

FicherosTamañoFormatoVer

No hay ficheros asociados a este ítem.

Este ítem aparece en la(s) siguiente(s) colección(ones)

Mostrar el registro sencillo del ítem

Attribution-NonCommercial-NoDerivatives 4.0 InternationalExcepto si se señala otra cosa, la licencia del ítem se describe como Attribution-NonCommercial-NoDerivatives 4.0 International