Global Respiratory Syncytial Virus-Related Infant Community Deaths

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URI: http://hdl.handle.net/10818/53947Visitar enlace: https://pubmed.ncbi.nlm.nih.go ...
ISSN: 1537-6591
DOI: 10.1093/cid/ciab528
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Mazur N.I; Löwensteyn Y.N; Willemsen J.E; Gill CJ; Forman L.; Mwananyanda L.M; Blau DM; Breiman R.F; Madhi S.A; Mahtab S.; Gurley E.SFecha
2021Resumen
Background: Respiratory syncytial virus (RSV) is a leading cause of pediatric death, with >99% of mortality occurring in low- and lower middle-income countries. At least half of RSV-related deaths are estimated to occur in the community, but clinical characteristics of this group of children remain poorly characterized.
Methods: The RSV Global Online Mortality Database (RSV GOLD), a global registry of under-5 children who have died with RSV-related illness, describes clinical characteristics of children dying of RSV through global data sharing. RSV GOLD acts as a collaborative platform for global deaths, including community mortality studies described in this supplement. We aimed to compare the age distribution of infant deaths <6 months occurring in the community with in-hospital.
Results: We studied 829 RSV-related deaths <1 year of age from 38 developing countries, including 166 community deaths from 12 countries. There were 629 deaths that occurred <6 months, of which 156 (25%) occurred in the community. Among infants who died before 6 months of age, median age at death in the community (1.5 months; IQR: 0.8-3.3) was lower than in-hospital (2.4 months; IQR: 1.5-4.0; P < .0001). The proportion of neonatal deaths was higher in the community (29%, 46/156) than in-hospital (12%, 57/473, P < 0.0001).
Conclusions: We observed that children in the community die at a younger age. We expect that maternal vaccination or immunoprophylaxis against RSV will have a larger impact on RSV-related mortality in the community than in-hospital. This case series of RSV-related community deaths, made possible through global data sharing, allowed us to assess the potential impact of future RSV vaccines.
Ubicación
Clin Infect Dis. 2021 Sep 2;73(Suppl_3):S229-S237
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- Facultad de Medicina [1454]