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Modulation of thyroid hormone receptor transactivation by the early region 1A (E1A)-like inhibitor of differentiation 1 (EID1)
dc.contributor.author | Vargas, Diana | |
dc.contributor.author | Celis Regalado, Luis Gustavo | |
dc.contributor.author | Lizcano Losada, Fernando | |
dc.date.accessioned | 10/19/2020 15:14 | |
dc.date.available | 2020-10-19T20:14:30Z | |
dc.date.issued | 2007-09-18 | |
dc.identifier.issn | 1415-4757 | |
dc.identifier.other | https://www.scielo.br/scielo.php?pid=S1415-47572008000300003&script=sci_abstract | |
dc.identifier.uri | http://hdl.handle.net/10818/43700 | |
dc.description | 7 páginas | es_CO |
dc.description.abstract | Transcriptional activation (TA) mediated by the effect of thyroid hormones on target genes requires co-activator proteins such as the early region 1A (E1A) associated 300 kDa binding protein (p300) and the cAMP response element binding protein (CREB) binding protein (CBP), known as the p300/CBP complex, which acetylate histones 3 and 4 to allow transcriptional machinery access to the target gene promoter. Little is known on the role of p300 in thyroid hormone receptor (TR) mediated TA but the E1A-like inhibitor of differentiation 1 (EID1), an inhibitor of p300 histone acetyltransferase (HAT), is a functional homolog of E1A and may inhibit myogenic differentiation factor D (MyoD) transcriptional activity and reduces muscle cell differentiation. We evaluated the influence of EID1 on TR-mediated transcriptional activity using transfection and mammalian two-hybrid studies to show that EID1 may partially reduces TA activity of the TR receptor, probably due to p300 blockage since EID1 mutants cannot reduce TR-mediated TA. The EID1 does not affect the function of p160 co-activator proteins (160 kDa proteins of steroid receptor co-activators) and is functionally independent of co-repressor proteins or TR binding. Summarizing, EID1 reduces TR-mediated transcriptional activity by blocking p300 and may play an important role in thyroid receptor activity in muscle and other tissues. | en |
dc.format | application/pdf | es_CO |
dc.language.iso | eng | es_CO |
dc.publisher | Genetics and Molecular Biology | es_CO |
dc.relation.ispartofseries | Genetics and Molecular Biology, 31, 2, 409-415 (2008) | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 International | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.source | Universidad de La Sabana | es_CO |
dc.source | Intellectum Repositorio Universidad de La Sabana | es_CO |
dc.subject.other | Co-activator | en |
dc.subject.other | EID1 | en |
dc.subject.other | p300 | en |
dc.subject.other | Thyroid receptors | en |
dc.subject.other | Transcription | en |
dc.title | Modulation of thyroid hormone receptor transactivation by the early region 1A (E1A)-like inhibitor of differentiation 1 (EID1) | es_CO |
dc.type | article | en |
dc.type.hasVersion | publishedVersion | es_CO |
dc.rights.accessRights | openAccess | es_CO |
dc.identifier.doi | 10.1590/S1415-47572008000300003 | |
dc.identifier.eissn | 1678-4685 |
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