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dc.contributor.authorGarcía Serrano, Jeison
dc.contributor.authorLizcano, Fernando
dc.date.accessioned10/3/2020 7:09
dc.date.available2020-10-03T12:09:14Z
dc.date.issued2018-07-27
dc.identifier.issn1178-2234
dc.identifier.otherhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6073829/
dc.identifier.urihttp://hdl.handle.net/10818/43495
dc.description8 páginases_CO
dc.description.abstractMembers of the jumonji-containing lysine demethylase protein family have been associated with cancer development, although their specific roles in the evolution of tumor cells remain unknown. This work examines the effects of lysine demethylase 4C (KDM4C) knockdown on the behavior of a triple-negative breast cancer cell line. KDM4C expression was knocked-down by siRNA and analyzed by Western blot and immunofluorescence. HCC38 cell proliferation was examined by MTT assay, while breast cancer cells’ migration and invasion were tested in Transwell format by chemotaxis. Immunofluorescence assays showed that KDM4C, which is a key protein for modulating histone demethylation and chromosome stability through the distribution of genetic information, is located at the chromosomes during mitosis. Proliferation assays demonstrated that KDM4C is important for cell survival, while Transwell migration and invasion assays indicated that this protein is relevant for cancer progression. These data indicate that KDM4C is relevant for breast cancer progression and highlight its importance as a potential therapeutic target.en
dc.formatapplication/pdfes_CO
dc.language.isoenges_CO
dc.publisherBreast Cancer (Auckl)es_CO
dc.relation.ispartofseriesBreast Cancer (Auckl). 2018;12
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.sourceUniversidad de La Sabanaes_CO
dc.sourceIntellectum Repositorio Universidad de La Sabanaes_CO
dc.subjectChromosome segregationes_CO
dc.subjectJumonji domain-containing histone demethylaseses_CO
dc.subjectRNA interferencees_CO
dc.subjectTriple-negative breast neoplasmses_CO
dc.titleKdm4c is Recruited to Mitotic Chromosomes and Is Relevant for Chromosomal Stability, Cell Migration and Invasion of Triple Negative Breast Cancer Cellses_CO
dc.typearticleen
dc.type.hasVersionpublishedVersiones_CO
dc.rights.accessRightsopenAccesses_CO
dc.identifier.doi10.1177/1178223418773075


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