Participation of the infralimbic cortex on the initial modulation of the reacquisition of odor discrimination task

Prada Acosta, Lina Paola

dc.contributor.author	Prada Acosta, Lina Paola
dc.date.accessioned	2020-09-01T16:40:01Z
dc.date.available	2020-09-01T16:40:01Z
dc.date.issued	2020-07-13
dc.identifier.uri	http://hdl.handle.net/10818/43101
dc.description	23 páginas	es_CO
dc.description.abstract	The mechanisms by which the infralimbic cortex (IL) participates in cognitive flexibility (cognitive flexibility) in odors discrimination task (ODT) remain poorly understood. Two experiments were carried out on male Wistar rats that were submitted to infusions of bilateral N-methyl-D-aspartate (NMDA) in IL post-training of ODT and they were compared to a Vehicle group. In experiment I, we evaluated the effect of the lesion in a four-trial session, where the spatial component was rotated according to clockwise. In experiment II, the effects of the lesion were assessed in a five-trial session, in which the spatial component was rotated randomly. The results show that the animals had a deterioration both both latenc and total errors during the first trials only in reacquisition (RAC); however, in perseverance, no deficit was seen. These data suggest that the IL might play a role in the modulation of the initial phase of the RAC in ODT, possibly by deafferentation of the role that IL has within the cortical-limbicstriated circuit, especially with the anterior cingulate cortex.	eng
dc.format	application/pdf	es_CO
dc.language.iso	spa	es_CO
dc.publisher	Universidad de La Sabana	es_CO
dc.rights	Attribution-NonCommercial-NoDerivatives 4.0 International	*
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/4.0/	*
dc.source	instname:Universidad de La Sabana	es_CO
dc.source	reponame:Intellectum Repositorio Universidad de La Sabana	es_CO
dc.subject	Psicología experimental	es_CO
dc.subject	Animales -- Hábitos y conducta	es_CO
dc.subject	Conducta humana	es_CO
dc.subject	Corteza prefrontal	es_CO
dc.subject	Percepción -- Pruebas	es_CO
dc.subject	Control de olores	es_CO
dc.title	Participation of the infralimbic cortex on the initial modulation of the reacquisition of odor discrimination task	eng
dc.title.alternative	Participación de la corteza infralímbica en la modulación inicial de la tarea de readquisición de discriminación de olores
dc.type	bachelorThesis	es_CO
dc.publisher.program	Psicología	es_CO
dc.publisher.department	Facultad de Psicología	es_CO
dc.identifier.local	277973
dc.identifier.local	TE10779
dc.type.hasVersion	publishedVersion	es_CO
dc.rights.accessRights	restrictedAccess	es_CO
dc.creator.degree	Psicólogo	es_CO
dcterms.references	Ashwell, R., & Ito, R. (2014). Excitotoxic lesions of the infralimbic, but not prelimbic cortex facilitate reversal of appetitive discriminative context conditioning: the role of the infralimbic cortex in context generalization. Frontiers in Behavioral Neuroscience,8,63. doi:10.3389/fnbeh.2014.00063	eng
dcterms.references	Barker, J. M., Torregrossa, M. M., & Taylor, J. R. (2013). Bidirectional modulation of infralimbic dopamine D1 and D2 receptor activity regulates flexible reward seeking. Frontiers in Neuroscience, 7, 126. doi:10.3389/fnins.2013.00126	eng
dcterms.references	Birrell, J. M., & Brown, V. J. (2000). Medial frontal cortex mediates perceptual attentional set shifting in the rat. Journal of Neuroscience, 20(11), 4320-4324	reng
dcterms.references	Bloodgood, D. W., Sugam, J. A., Holmes, A., & Kash, T. L. (2018). Fear extinction requires infralimbic cortex projections to the basolateral amygdala. Translational Psychiatry, 8(1). doi:10.1038/s41398-018-0106-x	eng
dcterms.references	Boulougouris, V., Dalley, J. W., & Robbins, T. W. (2007). Effects of orbitofrontal, infralimbic and prelimbic cortical lesions on serial spatial reversal learning in the rat. Behavioural Brain Research, 179(2), 219–228. doi:10.1016/j.bbr.2007.02.005	eng
dcterms.references	Boulougouris, V., & Robbins, T. W. (2009). Pre-surgical training ameliorates orbitofrontalmediated impairments in spatial reversal learning. Behavioural brain research, 197(2), 469-475. doi:10.1016/j.bbr.2008.10.005	eng
dcterms.references	Burgos-Robles, A., Bravo-Rivera, H., & Quirk, G. J. (2013). Prelimbic and Infralimbic Neurons Signal Distinct Aspects of Appetitive Instrumental Behavior. PLoS ONE, 8(2), e57575. doi:10.1371/journal.pone.0057575	eng
dcterms.references	Bussey, T. J., Muir, J. L., Everitt, B. J., & Robbins, T. W. (1997). Triple dissociation of anterior cingulate, posterior cingulate, and medial frontal cortices on visual discrimination tasks using a touchscreen testing procedure for the rat. Behavioral Neuroscience, 111(5), 920– 936. doi:10.1037/0735-7044.111.5.920	eng
dcterms.references	Brushfield, A. M., Luu, T. T., Callahan, B. D., & Gilbert, P. E. (2008). A comparison of discrimination and reversal learning for olfactory and visual stimuli in aged rats. Behavioral neuroscience, 122(1), 54-62. doi.org/10.1037/0735-7044.122.1.54	eng
dcterms.references	Chudasama, Y., & Robbins, T. W. (2003). Dissociable Contributions of the Orbitofrontal and Infralimbic Cortex to Pavlovian Autoshaping and Discrimination Reversal Learning: Further Evidence for the Functional Heterogeneity of the Rodent Frontal Cortex. The Journal of Neuroscience, 23(25), 8771–8780. doi:10.1523/jneurosci.23-25-08771.2003	eng
dcterms.references	Dalton, G. L., Wang, N. Y., Phillips, A. G., & Floresco, S. B. (2016). Multifaceted contributions by different regions of the orbitofrontal and medial prefrontal cortex to probabilistic reversal learning. Journal of Neuroscience, 36(6),1996-2006. doi:10.1523/jneurosci.3366-15.2016	eng
dcterms.references	Dhawan, S. S., Tait, D. S., & Brown, V. J. (2019). More rapid reversal learning following overtraining in the rat is evidence that behavioural and cognitive flexibility are dissociable. Behavioural brain research, 363, 45-52.doi:10.1016/j.bbr.2019.01.055	eng
dcterms.references	Elston, T. W., Croy, E., & Bilkey, D. K. (2019). Communication between the anterior cingulate cortex and ventral tegmental area during a cost-benefit reversal task. Cell reports, 26(9), 2353-2361.e3. doi:10.1016/j.celrep.2019.01.113	eng
dcterms.references	Ferry, A. T., Lu, X. C. M., & Price, J. L. (2000). Effects of excitotoxic lesions in the ventral striatopallidal–thalamocortical pathway on odor reversal learning: inability to extinguish an incorrect response. Experimental Brain Research, 131(3), 320-335. doi:10.1007/s002219900240	eng
dcterms.references	Fitoussi, A., Renault, P., Le Moine, C., Coutureau, E., Cador, M., & Dellu-Hagedorn, F. (2018). Inter-individual differences in decision-making, flexible and goal-directed behaviors: novel insights within the prefronto-striatal networks. Brain Structure and Function, 223(2), 897-912. doi:10.1007/s00429-017-1530-z	eng
dcterms.references	Gisquet-Verrier, P., & Delatour, B. (2006). The role of the rat prelimbic/infralimbic cortex in working memory: not involved in the short-term maintenance but in monitoring and processing functions. Neuroscience, 141(2),585-596. doi.org/ 10.1016/ j.neuroscience.2006.04.009	eng
dcterms.references	Hayen, A., Tamuri, S., Gates, A., & Ito, R. (2014). Opposing roles of prelimbic and infralimbic dopamine in conditioned cue and place preference. Psychopharmacology, 231(12), 2483-2492. doi:10.1007/s00213-013-3414-0	eng
dcterms.references	Hamilton, D. A., & Brigman, J. L. (2015). Behavioral flexibility in rats and mice: contributions of distinct frontocortical regions. Genes, Brain and Behavior, 14(1), 4-21. doi:10.1111/gbb.12191	eng
dcterms.references	Hoover, W., & Vertes, R. (2007). Anatomical analysis of afferent projections to the medial prefrontal cortex in the rat. Brain Structure and Function, 212(2), 149-179. doi: 10.1007/s00429-007-0150-4	eng
dcterms.references	Hoover, W. B., & Vertes, R. P. (2012). Collateral projections from nucleus reuniens of thalamus to hippocampus and medial prefrontal cortex in the rat: a single and double retrograde fluorescent labeling study. Brain Structure & Function, 217(2), 191-209. doi:10.1007/s00429-011-0345-6	eng
dcterms.references	Khalaf, O., & Gräff, J. (2019). Reactivation of recall-induced neurons in the infralimbic cortex and the basolateral amygdala after remote fear memory attenuation. Frontiers in Molecular Neuroscience, 12, 70. doi:10.3389/fnmol.2019.00070	eng
dcterms.references	Kim, J., & Ragozzino, M. E. (2005). The involvement of the orbitofrontal cortex in learning under changing task contingencies. Neurobiology of learning and memory, 83(2), 125- 133. doi:10.1016/j.nlm.2004.10.003	eng
dcterms.references	Klanker, M., Post, G., Joosten, R., Feenstra, M., & Denys, D. (2013). Deep brain stimulation in the lateral orbitofrontal cortex impairs spatial reversal learning. Behavioural brain research, 245, 7-12. doi:10.1016/j.bbr.2013.01.043	eng
dcterms.references	Li, L., & Shao, J. (1998). Restricted lesions to ventral prefrontal subareas block reversal learning but not visual discrimination learning in rats. Physiology & Behavior, 65(2), 371–379. doi:10.1016/s0031-9384(98)00216-9	eng
dcterms.references	Oualian, C., & Gisquet-Verrier, P. (2010). The differential involvement of the prelimbic and infralimbic cortices in response conflict affects behavioral flexibility in rats trained in a new automated strategy-switching task. Learning and Memory, 17(12), 654–668. doi.org/10.1101/lm.1858010	eng
dcterms.references	Paxinos,G., & Watson, C. (2006). The rat brain in stereotaxic coordinates (6th ed.). Sydney, Australia: Academic Press.	eng
dcterms.references	Quiroz-Padilla, M. F., Guillazo-Blanch, G., Vale-Martínez, A., Torras-García, M., & MartíNicolovius, M. (2007). Effects of parafascicular excitotoxic lesions on two-way active avoidance and odor-discrimination. Neurobiology of learning and memory, 88(2), 198- 207. doi:10.1016/j.nlm.2007.06.002	eng
dcterms.references	Ragozzino, M. E. (2007). The contribution of the medial prefrontal cortex, orbitofrontal cortex, and dorsomedial striatum to behavioral flexibility. Annals of the New York academy of sciences, 1121(1), 355-375. doi:10.1196/annals.1401.013	eng
dcterms.references	Ragozzino, M. E., Detrick, S., & Kesner, R. P. (1999). Involvement of the prelimbic– infralimbic areas of the rodent prefrontal cortex in behavioral flexibility for place and response learning. Journal of Neuroscience, 19(11), 4585-4594.	eng
dcterms.references	Ragozzino, M. E., & Rozman, S. (2007). The effect of rat anterior cingulate inactivation on cognitive flexibility. Behavioral neuroscience, 121(4), 698-706. doi.org/10.1037/ 0735-7044.121.4.698	eng
dcterms.references	Ragozzino, M. E., Kim, J., Hassert, D., Minniti, N., & Kiang, C. (2003). The contribution of the rat prelimbic-infralimbic areas to different forms of task switching. Behavioral Neuroscience, 117(5), 1054–1065. doi:10.1037/0735-7044.117.5.1054	eng
dcterms.references	Russo, A. S., Lee, J., & Parsons, R. G. (2019). Individual variability in the recall of fear extinction is associated with phosphorylation of mitogen-activated protein kinase in the infralimbic cortex. Psychopharmacology. doi:10.1007/s00213-019-05195-2	eng
dcterms.references	Torras-Garcia, M., Lelong, J., Tronel, S., & Sara, S. J. (2005). Reconsolidation after remembering an odor-reward association requires NMDA receptors. Learning & memory, 12(1), 18-22	eng
dcterms.references	Tronel, S., & Sara, S. J. (2002). Mapping of olfactory memory circuits: region-specific c-fos activation after odor-reward associative learning or after its retrieval. Learning & Memory, 9(3), 105-111.doi:10.1101/lm.47802	eng
dcterms.references	Wood, M., Adil, O., Wallace, T., Fourman, S., Wilson, S. P., Herman, J. P., & Myers, B. (2019). Infralimbic prefrontal cortex structural and functional connectivity with the limbic forebrain: a combined viral genetic and optogenetic analysis. Brain Structure and Function, 224(1), 73–97. https://doi.org/10.1007/s00429-018-1762-6	eng
dcterms.references	Zeeb, F. D., Baarendse, P. J. J., Vanderschuren, L. J. M. J., & Winstanley, C. A. (2015). Inactivation of the prelimbic or infralimbic cortex impairs decision-making in the rat gambling task. Psychopharmacology, 232(24), 4481–4491. doi:10.1007/s00213-015- 4075-y	eng