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dc.contributor.authorSantos, Ana M.
dc.contributor.authorPeña, Paola
dc.contributor.authorAvila, Mabel
dc.contributor.authorBriceño Balcázar, Ignacio
dc.contributor.authorJaramillo, Carlos
dc.contributor.authorVargas Alarcon, Gilberto
dc.contributor.authorRueda, Juan C.
dc.contributor.authorSaldarriaga, Eugenia Lucia
dc.contributor.authorAngarita, Jose Ignacio
dc.contributor.authorMartinez Rodriguez, Nancy
dc.contributor.authorLondoño, John
dc.description6 páginases_CO
dc.description.abstractThere is substantial evidence that non-B27 major histocompatibility complex (MHC) genes are associated with spondyloarthritis (SpA). Studies in Mexican and Tunisian populations demonstrated the association of SpA and human leukocyte antigen (HLA) B15. The purpose of this study was to evaluate the association of HLA-A, B, and DR antigens in a group of Colombian patients with a diagnosis of SpA. A total of 189 patients and 100 healthy subjects were included in the present study. All subjects underwent a complete characterization of HLA alleles A, B, and DR. Of the 189 studied patients, 35 were reactive arthritis (ReA), 87 were ankylosing spondylitis (AS), and 67 undifferentiated SpA (uSpA). According to the Assessment of Spondyloarthritis International Society (ASAS) criteria, 167 were axial SpA (axSpA) and 171 were peripheral SpA (pSpA). 63.8% were men, with a mean age of 35.9 ± 12.7 years. 40.7% (77/189) of patients were HLA-B27 positive of which 52.9% had AS and 42.5% axSpA. 23.2% (44/189) of patients were HLA-B15 positive: 23.8% were uSpA, 12.57% were axSpA, and 11.7% were pSpA. In addition, HLA-DRB1*01 was associated with AS (58.6%) and axSpA (42.5%). Also, HLA-DRB1*04 was present in 62 patients with AS (71.2%) and in 26 with axSpA (15.5%). In this population, we found a strong association between the presence of HLA-B27 and the diagnosis of axSpA and AS, but the HLA-B15 is also significantly associated with all subtypes of the disease, predominantly with pSpA. Additionally, HLA-DR1 and DR4 were associated in a cohort of patients with SpA from Colombia.eng
dc.publisherClinical Rheumatologyes_CO
dc.relation.ispartofseriesClin Rheumatol . 2017 Abr;36 (4): 953-958
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.sourceinstname:Universidad de La Sabanaes_CO
dc.sourcereponame:Intellectum Repositorio Universidad de La Sabanaes_CO
dc.subjectAllele frequencyes_CO
dc.titleAssociation of human leukocyte A, B, and DR antigens in Colombian patients with diagnosis of spondyloarthritises_CO
dc.title.alternativeAsociación de antígenos leucocitarios humanos A, B y DR en pacientes colombianos con diagnóstico de espondiloartritises_CO
dc.identifier.doi10.1007 / s10067-016-3516-2

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Attribution-NonCommercial-NoDerivatives 4.0 InternationalExcept where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivatives 4.0 International