| dc.contributor.author | Guerra Rodriguez, Nelson | |
| dc.contributor.author | Reyes Velazco, Luis Felipe | |
| dc.contributor.author | Bastidas Goyes, Alirio Rodrigo | |
| dc.contributor.author | Bustos Moya, Ingrid Gisell | |
| dc.contributor.author | Josa Montero, Diego Fernando | |
| dc.contributor.author | Silva Monsalve, Edwin | |
| dc.date.accessioned | 2019-12-03T20:07:46Z | |
| dc.date.available | 2019-12-03T20:07:46Z | |
| dc.date.issued | 2019-11-05 | |
| dc.identifier.uri | http://hdl.handle.net/10818/38610 | |
| dc.description | 33 páginas | es_CO |
| dc.description.abstract | Las infecciones por bacterias multirresistentes o multidrug resistant pathogens (MDRP) son una epidemia y por lo tanto representa un problema de salud pública, especialmente en los pacientes hospitalizados en la Unidad de Cuidados Intensivos (UCI). El retraso en el inicio de la terapia antibiótica adecuada en los pacientes hospitalizados con sepsis incrementa la mortalidad exponencialmente. En la actualidad, algunos factores de riesgo para infecciones por un MDRP han sido documentados, sin embargo, las investigaciones existentes apuntan a un tipo de infección o un patógeno especifico, no abordando el problema de forma global al ingreso a la UCI. Por lo tanto, el presente trabajo tiene como fin identificar los factores de riesgo predictores de infección por bacterias MDRP productoras de betalactamasas de espectro extendido (BLEE) en pacientes admitidos a la UCI por sepsis en general; lo cual permitirá la implementación de estrategias para el control de las infecciones y selección correcta del antibiótico empírico con el fin de mejorar los desenlaces clínicos. | es_CO |
| dc.language.iso | spa | es_CO |
| dc.publisher | Universidad de La Sabana | es_CO |
| dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 International | * |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
| dc.source | Universidad de La Sabana | |
| dc.source | Intellectum Repositorio Universidad de La Sabana | |
| dc.subject | Infección hospitalaria | es_CO |
| dc.subject | Bacterias | es_CO |
| dc.subject | Salud pública | es_CO |
| dc.subject | Unidades de cuidados intensivos | es_CO |
| dc.subject | Antibióticos | es_CO |
| dc.subject | Betalactamasas de espectro extendido | |
| dc.title | Factores de riesgo para infección por bacterias multirresistentes de fenotipo blee en pacientes en estado crítico: un modelo de predicción automatizado: un modelo de predicción automatizado | es_CO |
| dc.type | bachelorThesis | es_CO |
| dc.publisher.program | Farmacología Clínica | |
| dc.publisher.department | Facultad de Medicina | |
| dc.rights.accessRights | restrictedAccess | |
| dc.creator.degree | Especialista en Farmacología Clínica | |
| dcterms.references | 1, Paramythiotou E, Routsi C. Association between infections caused by multidrug-resistant
gram-negative bacteria and mortality in critically ill patients. World Journal of Critical Care
Medicine. 2016;5(2):111-120. | eng |
| dcterms.references | 2. Raoult D, Leone M, Roussel Y, Rolain J. Attributable deaths caused by infections with
antibiotic-resistant bacteria in France. The Lancet Infectious Diseases. 2019;19(2):128-129 | eng |
| dcterms.references | 3. Cassini A, Högberg L, Plachouras D, Quattrocchi A, Hoxha A, Simonsen G et al.
Attributable deaths and disability-adjusted life-years caused by infections with antibioticresistant bacteria in the EU and the European Economic Area in 2015: a population-level
modelling analysis. The Lancet Infectious Diseases. 2019;19(1):56-66. | eng |
| dcterms.references | 4. OECD (2018), Stemming the Superbug Tide: Just A Few Dollars More, OECD Health
Policy Studies, OECD Publishing, Paris. | eng |
| dcterms.references | 5. Sader H, Jones R, Gales A, Silva J, Pignatari A. SENTRY antimicrobial surveillance
program report: latin american and brazilian results for 1997 through 2001. Brazilian Journal
of Infectious Diseases. 2004;8(1):25-79 | eng |
| dcterms.references | 6. Villalobos A, Barrero L, Rivera S, Ovalle M, Valera D. Vigilancia de infecciones
asociadas a la atención en salud, resistencia bacteriana y consumo de antibióticos en
hospitales de alta complejidad, Colombia, 2011. Biomédica. 2013;34(supl.1):67-80. | spa |
| dcterms.references | 7. Barrero L, Castillo J, Leal A, Sánchez R, Cortés J, Álvarez C et al. Impacto económico de
la resistencia a meticilina en pacientes con bacteriemia por Staphylococcus aureus en
hospitales de Bogotá. Biomédica. 2014;34(3):345-353. | spa |
| dcterms.references | 8. Lemos E, de la Hoz F, Alvis N, Quevedo E, Einarson T, Castañeda C et al. Costos en
pacientes con infección por Acinetobacter baumannii en Colombia. Infectio. 2013;17(4):185-
192. | spa |
| dcterms.references | 9. Zhen X, Lundborg C, Sun X, Hu X, Dong H. Economic burden of antibiotic resistance in
ESKAPE organisms: a systematic review. Antimicrobial Resistance & Infection Control.
2019;8(1):137. | eng |
| dcterms.references | 10. Fernández T. Uso y abuso de antibióticos. Archivo médico de Camagüey.
2013;17(5):525-527. | spa |
| dcterms.references | 11. Londoño Restrepo J, Macias Ospina I, Ochoa Jaramillo F. Factores de riesgo asociados a
infecciones por bacterias multirresistentes derivadas de la atención en salud en una institución
hospitalaria de la ciudad de Medellín 2011-2014. Infectio. 2016;20(2):77-83. | spa |
| dcterms.references | 12. Vera-Leiva A, Barría-Loaiza C, Carrasco-Anabalón S, Lima C, Aguayo-Reyes A,
Domínguez M et al. KPC: Klebsiella pneumoniae carbapenemasa, principal carbapenemasa
en enterobacterias. Revista chilena de infectología. 2017;34(5):476-484. | spa |
| dcterms.references | 13. Rodríguez E, Saavedra S, Leal A, Álvarez C, Olarte N, Valderrama A et al. Diseminación
de Klebsiella pneumoniae productoras de KPC-3 en hospitales de Bogotá durante un periodo
de tres años. Biomédica. 2014;34(Supl.1):224-231. | spa |
| dcterms.references | 14. Jeong B, Koh W, Yoo H, Park H, Suh G, Chung M et al. Risk Factors for Acquiring
Potentially Drug-Resistant Pathogens in Immunocompetent Patients with Pneumonia
Developed Out of Hospital. Respiration. 2014;88(3):190-198. | eng |
| dcterms.references | 15. Fernandes P, Dantas L, de Madureira P. Predicting factors for infection or colonization by
multidrugresistant bacteria in a general hospital: a case-control study. Journal of Infection
Control. 2013;2(2):117-123. | eng |
| dcterms.references | 16. Aliberti S, Reyes L, Faverio P, Sotgiu G, Dore S, Rodriguez A et al. Global initiative for
meticillin-resistant Staphylococcus aureus pneumonia (GLIMP): an international
observational cohort study. The lancet infectious disease. 2016;16(12): 1364-1376 | eng |
| dcterms.references | 17. Cohen R, Babushkin F, Cohen S, Afraimov M, Shapiro M, Uda M et al. A prospective
survey of Pseudomonas aeruginosa colonization and infection in the intensive care unit.
Antimicrobial Resistance & Infection Control. 2017;6(1): 7. | eng |
| dcterms.references | 18. Metlay J, Waterer G, Long A, Anzueto A, Brozek J, Cooley L et al. Diagnosis and
treatment of adults with community-acquired pneumonia an official clinical practice
guideline of the american thoracic society and infectious diseases society of america.
American Journal of Respiratory and Critical Care Medicine. 2019;200(7): e45-e67. | eng |
| dcterms.references | 19. Cardoso T, Ribeiro O, Aragão I, Costa-Pereira A, Sarmento A. Additional risk factors for
infection by multidrug-resistant pathogens in healthcare-associated infection: a large cohort
study. BMC Infectious Diseases. 2012;12(1): 375. | eng |
| dcterms.references | 20. Joseph N, Sistla S, Dutta T, Badhe A, Rasitha D, Parija S. Ventilator-associated
pneumonia in a tertiary care hospital in india: role of multi-drug resistant pathogens. The
Journal of Infection in Developing Countries. 2010;4(4):218-225. | eng |
| dcterms.references | 21. Harinstein L, Schafer J, D'Amico F. Risk factors associated with the conversion of
meticillin-resistant Staphylococcus aureus colonisation to healthcare-associated infection.
Journal of Hospital Infection. 2011;79(3):194-197. | eng |
| dcterms.references | 22. Xie J, Ma X, Huang Y, Mo M, Guo F, Yang Y et al. Value of American Thoracic Society
Guidelines in Predicting Infection or Colonization with Multidrug-Resistant Organisms in
Critically Ill Patients. PLoS ONE. 2014;9(3): e89687. | eng |
| dcterms.references | 23. Performance standards for antimicrobial susceptibility testing. 29th ed. CLSI supplement
M100. Wayne, PA: Clinical and Laboratory Standards Institute; 2019. | eng |
| dcterms.references | 24. Harris PA, Taylor R, Thielke R, Payne J, Gonzalez N, Conde JG. Research electronic
data capture (REDCap)—a metadata-driven methodology and workfl ow process for
providing translational research informatics support. J Biomed Inform 2009; 42: 377–81. | eng |
| dcterms.references | 25. Magiorakos A, Srinivasan A, Carey R, Carmeli Y, Falagas M, Giske C et al. Multidrugresistant, extensively drug-resistant and pandrug-resistant bacteria: an international expert
proposal for interim standard definitions for acquired resistance. Clinical Microbiology and
Infection. 2012;18(3):268-281. | eng |
| dcterms.references | 26. Ghafourian S, Sadeghifard N, Soheili S, Sekawi Z. Extended Spectrum Beta-lactamases:
Definition, Classification and Epidemiology. Current Issues in Molecular Biology.
2015;17(1):11-22 | eng |
| dcterms.references | 27. Garnacho-Montero J, Gutiérrez-Pizarraya A, Escoresca-Ortega A, Fernández-Delgado E,
López-Sánchez J. Adequate antibiotic therapy prior to ICU admission in patients with severe
sepsis and septic shock reduces hospital mortality. Critical Care. 2015;19(1): 302. | eng |
| dcterms.references | 28. European Centre for Disease Prevention and Control. Healthcare-associated infections
acquired in intensive care units. In: ECDC. Annual epidemiological report for 2016.
Stockholm: ECDC; 2018. | eng |
| dcterms.references | 29. MacVane S. Antimicrobial Resistance in the Intensive Care Unit: A Focus on GramNegative Bacterial Infections. Journal of Intensive Care Medicine. 2017;32(1):25-37. | eng |
| dcterms.references | 30. Vincent J, de Mendonca A, Cantraine F, Moreno R, Takala J, Suter P et al. Use of the
SOFA score to assess the incidence of organ dysfunction/failure in intensive care units.
Critical Care Medicine. 1998;26(11):1793-1800. | eng |
| dcterms.references | 31. Liu Z, Meng Z, Li Y, Zhao J, Wu S, Gou S et al. Prognostic accuracy of the serum lactate
level, the SOFA score and the qSOFA score for mortality among adults with Sepsis.
Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine. 2019;27(1): 51. | eng |
| dcterms.references | 32. Tumbarello M, Trecarichi E, Bassetti M, De Rosa F, Spanu T, Di Meco E et al.
Identifying Patients Harboring Extended-Spectrum-β-Lactamase-Producing
Enterobacteriaceae on Hospital Admission: Derivation and Validation of a Scoring System.
Antimicrobial Agents and Chemotherapy. 2011;55(7):3485-3490. | eng |
| dcterms.references | 33. Mascitti H, Duran C, Nemo E, Bouchand F, Câlin R, Descatha A et al. Factors associated
with bacteraemia due to multidrug-resistant organisms among bacteraemic patients with
multidrug-resistant organism carriage: a case control study. Antimicrobial Resistance &
Infection Control. 2018;7(1): 116. | eng |
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