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dc.contributor.authorPrada Rico, Mayerly
dc.contributor.authorFernández Sarmiento, Jaime
dc.contributor.authorRojas Velasquez, Ana María
dc.contributor.authorGonzález Chaparro, Luz Stella
dc.contributor.authorGastelbondo Amaya, Ricardo
dc.contributor.authorMulett Hoyos, Hernando
dc.contributor.authorTibaduiza, Daniel
dc.contributor.authorQuintero Gómez, Ana Maria 10:50
dc.identifier.citationRico, M.P., Fernández Sarmiento, J., Rojas Velasquez, A.M. et al. Pediatr Nephrol (2017) 32: 703.
dc.description9 páginases_CO
dc.description.abstractBackground Anticoagulation of the continuous renal replacement therapy (CRRT) circuit is an important technical aspect of this medical procedure. Most studies evaluating the efficacy and safety of citrate use have been carried out in adults, and little evidence is available for the pediatric patient population. The aim of this study was to compare regional citrate anticoagulation versus systemic heparin anticoagulation in terms of the lifetime of hemofilters in a pediatric population receiving CRRT at a pediatric center in Bogota, Colombia. Methods This was an analytical, observational, retrospective cohort study in which we assessed the survival of 150 hemofilters (citrate group 80 hemofilters, heparin group 70 hemofilters) used in a total of 3442 hours of CCRT (citrate group 2248 h, heparin group 1194 h). Hemofilter survival was estimated beginning at placement and continuing until filter replacement due to clotting or high trans-membrane pressures. Results Hemofilter survival was higher in the citrate group than in the heparin group (72 vs. 18 h; p <0.0001). Bivariate analysis showed that the hemofilter coagulation risk was significantly increased when heparin was used, regardless of hemofilter size and pump flow (hazard ratio 3.70, standard error 0.82, 95% confidence interval 2.39–5.72; p <0.00001). Conclusions Regional citrate anticoagulation could be more effective than heparin systemic anticoagulation in terms of prolonging the hemofilter lifetime in patients with acute renal injury who require CRRT.en
dc.publisherPediatric Nephrologyes_CO
dc.relation.ispartofseriesPediatr Nephrol (2017) 32: 703
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.sourceUniversidad de La Sabanaes_CO
dc.sourceIntellectum Repositorio Universidad de La Sabanaes_CO
dc.subjectContinuous renal replacement therapyes_CO
dc.titleRegional citrate anticoagulation for continuous renal replacement therapy in childrenes_CO

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Attribution-NonCommercial-NoDerivatives 4.0 InternationalExcept where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivatives 4.0 International