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dc.contributor.authorVillamor, Eduardo
dc.contributor.authorMarín, Constanza
dc.contributor.authorMora Plazas, Mercedes
dc.contributor.authorOliveros Rodríguez, Henry
dc.date.accessioned7/17/2019 10:15
dc.date.available2019-07-17T15:15:04Z
dc.date.issued2017-12
dc.identifier.issn1475-2662
dc.identifier.otherhttps://www.cambridge.org/core/journals/british-journal-of-nutrition/article/micronutrient-status-in-middle-childhood-and-age-at-menarche-results-from-the-bogota-school-children-cohort/D4396E109CB362F8B6CA4087E4AAD2E0
dc.identifier.urihttp://hdl.handle.net/10818/36193
dc.description9 páginases_CO
dc.description.abstractChildhood intake of animal foods is associated with age at first menstrual period (menarche). It is unknown whether the micronutrients present in these foods could explain this association. Our objective was to investigate the associations of micronutrient status biomarkers in middle childhood with age at menarche. We quantified circulating Hb, ferritin, mean corpuscular volume, Zn, vitamin B12, erythrocyte folate and retinol in 1464 pre-menarcheal girls aged 5–12 years in Bogotá, Colombia, and followed them for a median 5·7 years for the occurrence and date of menarche. We estimated median age at menarche and hazard ratios (HR) with 95 % CI by levels of each biomarker with use of Kaplan–Meier survival probabilities and Cox regression, respectively. Median age at menarche was 12·4 years. Middle childhood Hb was inversely related to age at menarche whereas plasma ferritin was positively associated with this outcome in a linear manner. HR of menarche for every 1 sd of Hb (11 g/l) and ferritin (23·2 µg/l) were 1·11 (95 % CI 1·04, 1·18; P=0·001) and 0·94 (95 % CI 0·88, 0·99; P=0·02), respectively, after adjustment for baseline age, C-reactive protein concentration, maternal age at menarche and parity and socioeconomic status. The association with ferritin was stronger in girls aged 9–10 years at baseline. Additional adjustment for baseline height- and BMI-for-age did not change the results. We conclude that higher Fe status in middle childhood is related to later age at menarche whereas Hb concentrations are inversely associated with age at onset of menses.en
dc.formatapplication/pdfes_CO
dc.language.isoenges_CO
dc.publisherBritish Journal of Nutritiones_CO
dc.relation.ispartofseriesBritish Journal of Nutrition (2017), 118, 1097–1105
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.sourceUniversidad de La Sabanaes_CO
dc.sourceIntellectum Repositorio Universidad de La Sabanaes_CO
dc.subjectMenarchees_CO
dc.subjectHbes_CO
dc.subjectFerritines_CO
dc.subjectMicronutrientses_CO
dc.subjectMiddle childhoodes_CO
dc.titleMicronutrient status in middle childhood and age at menarche: results from the Bogotá School Children Cohortes_CO
dc.typearticleen
dc.type.hasVersionpublishedVersiones_CO
dc.rights.accessRightsopenAccesses_CO
dc.identifier.doi10.1017/S0007114517003130


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