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Papel de la histona demetilasa kdm4c en el desarrollo del cáncer de seno triple negativo

dc.contributor.advisorLizcano Losada, Fernando
dc.contributor.authorGarcía Serrano, Jeison
dc.date.accessioned3/12/2019 11:22
dc.date.available3/12/2019 11:22
dc.date.issued2018-11-14
dc.identifier.urihttp://hdl.handle.net/10818/35133
dc.description123 páginases_CO
dc.description.abstractLa complejidad del ser humano se concentra en los más de 30000 genes que componen nuestro genoma, almacenando la información necesaria para la expresión de macromoléculas en espacio y tiempo específicos, permitiendo el mantenimiento del fenotipo celular [1]. La regulación de la expresión génica envuelve la modificación de la estructura compleja del ADN nuclear, alterando la complejidad del enrollamiento de la doble hebra en un octámero de proteínas histonas como parte de la unidad básica de la cromatina: el nucleosoma [2, 3]. El nucleosoma fue descrito por el premio nobel de química en 1974, Roger Kornberg [3], y está compuesto por un octámero de cuatro proteínas llamadas histonas (H3, H4, H2A y H2B), proteínas muy básicas alrededor de las cuales se enrollan 147 pares de bases de ADN dando 1,65 vueltas y cuya estructura se interconecta con los nucleosomas adyacentes mediante la histona H1.es_CO
dc.formatapplication/pdfes_CO
dc.language.isospaes_CO
dc.publisherUniversidad de La Sabanaes_CO
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.sourceUniversidad de La Sabana
dc.sourceIntellectum Repositorio Universidad de La Sabana
dc.subjectMacromoléculases_CO
dc.subjectGenéticaes_CO
dc.subjectADNes_CO
dc.subjectCromatinaes_CO
dc.subjectEnfermedades de la mama -- Cánceres_CO
dc.titlePapel de la histona demetilasa kdm4c en el desarrollo del cáncer de seno triple negativoes_CO
dc.typedoctoral thesises_CO
dc.identifier.local270587
dc.identifier.localTE09992
dc.type.hasVersionpublishedVersiones_CO
dc.rights.accessRightsopenAccesses_CO
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thesis.degree.disciplineFacultad de Ingenieríaes_CO
thesis.degree.levelDoctorado en Biocienciases_CO
thesis.degree.nameDoctor en Biocienciases_CO


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