Mostrar el registro sencillo del ítem

dc.contributor.authorVargas M.
dc.contributor.authorBustamante C.
dc.contributor.authorVillarraga EA.
dc.date.accessioned10/7/2019 11:52
dc.date.available2019-10-07T16:52:33Z
dc.date.issued2015
dc.identifier.otherhttps://www.longdom.org/open-access/bioequivalence-study-of-two-formulations-containing-irbesartan-300-mgtablets-in-healthy-colombian-volunteers-jbb-1000237.pdf
dc.identifier.urihttp://hdl.handle.net/10818/37543
dc.description5 páginases_CO
dc.description.abstractThis is a pharmacokinetic study of two formulations containing Irbesartan 300 mg. Its objective was to compare the Bioavailability between the Test product (Irbesartan produced by Tecnoquímicas S.A., Colombia laboratory) and the Reference product (Aprovel® produced by Sanofi Aventis laboratory) in order to be able to state the Bioequivalence between them. For this, an open label, two periods, two randomized sequences, crossover, single fasting 300 mg dose study was performed with an 8-day washout period between each period in 24 healthy volunteers and collection of 12 plasma samples between 0 and 48 hours. The analytical method used was HPLC. The 90% confidence interval for the Cmax parameter was between 83.0 – 113.9 with a 97.2 ratio; for the AUC0-t parameter the 90% CI it is between 92.1 -116.7 with a 103.7 ratio, and for the AUC0-∞ the 90% CI was found to be between 95.5 – 114.8 with a 104.7 ratio.en
dc.formatapplication/pdfes_CO
dc.language.isoenges_CO
dc.publisherJournal of J Bioequivalence & Bioavailabilityes_CO
dc.relation.ispartofseriesBioequiv Availab 2015, 7:4
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.sourceUniversidad de La Sabanaes_CO
dc.sourceIntellectum Repositorio Universidad de La Sabanaes_CO
dc.subjectBioequivalencees_CO
dc.subjectIrbesartanes_CO
dc.subjectAntihypertensivees_CO
dc.subjectPharmacokineticses_CO
dc.titleBioequivalence Study of Two Formulations Containing Irbesartan 300 Mg Tablets in Healthy Colombian Volunteerses_CO
dc.typearticleen
dc.type.hasVersionpublishedVersiones_CO
dc.rights.accessRightsopenAccesses_CO
dc.identifier.doi10.4172/jbb.1000237


Ficheros en el ítem

FicherosTamañoFormatoVer

No hay ficheros asociados a este ítem.

Este ítem aparece en la(s) siguiente(s) colección(ones)

Mostrar el registro sencillo del ítem

Attribution-NonCommercial-NoDerivatives 4.0 InternationalExcepto si se señala otra cosa, la licencia del ítem se describe como Attribution-NonCommercial-NoDerivatives 4.0 International