Rendimiento de la deuda de oxígeno (DEOx) para mortalidad a 28 días y falla orgánica múltiple en pacientes con COVID-19

Pérez Garzon, Michel; Poveda Henao, Claudia

dc.contributor.advisor	Bastidas Goyes, Alirio Rodrigo
dc.contributor.author	Pérez Garzon, Michel
dc.contributor.author	Poveda Henao, Claudia
dc.date.accessioned	2023-04-12T19:52:18Z
dc.date.available	2023-04-12T19:52:18Z
dc.date.issued	2023-02-10
dc.identifier.uri	http://hdl.handle.net/10818/54543
dc.description	21 páginas	es_CO
dc.description.abstract	Antecedente: La meta principal de paciente critico es mantener una adecuada DO2 a los tejidos, evitando la DEOx como indicador de DO2 crítico. El objetivo de este estudio es determinar la validez del DEOx a través de un cálculo cuantitativo indirecto para predecir FOM y mortalidad a 28 días en pacientes admitidos en UCI por infección por SARS-CoV-2 en relación al APACHE II, SOFA y 4C Score. Métodos: Estudio cohorte retrospectiva de pacientes con infección por SARS-CoV-2 admitidos en UCI entre el 2020 y 2021. Se calcularon al ingreso a UCI los scores de Acute Physiology and Chronic Health Evaluation (APACHE II), Sequential Organ Failure Assessment (SOFA) y 4C mortality comparando su precisión para predecir mortalidad a 28 días y FOM con el DEOx. Resultados: Se incluyeron 708 pacientes, con una tasa de mortalidad del 44,4% (n = 315), de los cuales 72,5% eran hombres con un valor de DEOx 11,16 mlO2/kg. La edad promedio fue de 58,7 (DE 14,51) años. El análisis multivariado se relaciona de manera independiente el DEOx para mortalidad, así como la intubación con OR de 8,69 (IC del 95%, 4.28 – 17.62) y lesión renal de 3,35 (IC del 95%, 2.40 – 4.68), y por cada punto de aumento de la creatinina el riesgo de FOM aumento con OR de 4.1 (IC del 95%, 1.87 – 8.98). Para determinar la precisión de las puntuaciones se realizó un análisis ACOR con una discriminación débil y comportamiento similar para los desenlaces primarios. La escala más precisa para mortalidad y FOM fueron el 4C con un AUC de 0.683 (IC del 95%, 0.64 – 0.72) y APACHE II con un AUC de 0,814 (IC del 95%, 0,77 - 0,85), mientras que el ACOR de DEOx fue 0,612 (IC del 95%, 0.57 – 0.65) y 0.646 (IC del 95%, 0.57 – 0.71) respectivamente. Conclusiones: La DEOx como predictor de FOM y mortalidad a 28 dias en paciente críticamente enfermo con SARS CoV 2 fue similar a los scores de APACHE II, SOFA y 4C.	es_CO
dc.format	application/pdf	es_CO
dc.language.iso	spa	es_CO
dc.publisher	Universidad de La Sabana	es_CO
dc.rights	Attribution-NonCommercial-NoDerivatives 4.0 Internacional	*
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/4.0/	*
dc.subject.other	Deuda de oxígeno
dc.title	Rendimiento de la deuda de oxígeno (DEOx) para mortalidad a 28 días y falla orgánica múltiple en pacientes con COVID-19	es_CO
dc.type	bachelor thesis	es_CO
dc.identifier.local	291576
dc.identifier.local	TE12216
dc.type.hasVersion	publishedVersion	es_CO
dc.rights.accessRights	openAccess	es_CO
dc.subject.armarc	COVID-19
dc.subject.armarc	Enfermos
dc.subject.armarc	Aparato respiratorio -- Enfermedades
dc.subject.armarc	Mortalidad
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thesis.degree.discipline	Facultad de Medicina	es_CO
thesis.degree.level	Especialización en Medicina Crítica y Cuidado Intensivo	es_CO
thesis.degree.name	Especialista en Medicina Crítica y Cuidado Intensivo	es_CO