FARMACOVID : Retrospective cohort study of the profile and 2 management of drug interactions in critically ill patients with 3 COVID-19 in a tertiary care hospital in Colombia

Abstract

Critically ill patients with COVID-19 have important risk factors for the occurrence of 21 drug-drug interactions. The aim of this study was to characterize and describe the profile and 22 management of drug-drug interactions in critically ill patients affected by COVID-19 in a tertiary 23 care hospital in Colombia. A descriptive retrospective cohort with an exploratory analytical com- 24 ponent was performed. The medical records of 191 patients were reviewed from August 2020 to 25 February 2021. An initial descriptive analysis was performed, and a bivariate approach was de- 26 veloped to include variables of significance in a multivariate analysis. In our cohort of critically ill 27 patients the following factors were associated with a higher risk of major outcome development: a 28 higher age, Charlson comorbidity index (CCI), Sequential Organ Failure Assessment (SOFA) 29 score, a greater number of prescribed drugs, number of interactions, and the presence of type D 30 interactions.