@misc{10818/34885,
year = {2018},
month = {2},
url = {http://hdl.handle.net/10818/34885},
abstract = {This study describes the development of a immunosensory label-free quantification methodology based on surface plasmon resonance (SPR) and its applicability in measuring/evaluating therapeutic drug monitoring (TDM) of anti-TNF-alpha monoclonal antibody (adalimumab) in rheumatoid arthritis (RA) patients. The experimental parameters evaluated in this study were immobilising ligands by pre-concentration assays, sensor surface regeneration, ascertaining the method’s sensitivity and correlating the results from quantifying plasma samples by ELISA immunoassay. The results showed that SPR immunosensory detection provided a precise, sensitive strategy, along with real-time determination, for quantifying adalimumab, having great potential for clinical routine regarding TDM},
publisher = {Universidad de La Sabana},
keywords = {Adalimumab},
keywords = {Medicamentos -- Efectos fisiológicos},
title = {Label-free quantification of anti-TNF-alpha in patients treated with adalimumab using an optical biosensor},
author = {Bustos Cruz, Rosa Helena and Zapata, Carlos and Esteban Mancera, Efraín Arsenio and García Casallas, Julio César and Jáuregui, Edwin and Jaimes Fernández, Diego Alejandro},
}