TY - GEN AU - Bastard, P. AU - Gervais, A. AU - Le Voyer, T. AU - Rosain, J. AU - Philippot, Q. PY - 2021 SN - 2470-9468 UR - http://hdl.handle.net/10818/53971 AB - Circulating autoantibodies (auto-Abs) neutralizing high concentrations (10 ng/mL, in plasma diluted 1 to 10) of IFN-α and/or -ω are found in about 10% of patients with critical COVID-19 pneumonia, but not in subjects with asymptomatic infections. We... LA - eng PB - Science immunology KW - COVID-19 KW - Age group TI - Autoantibodies neutralizing type I IFNs are present in ~ 4% of uninfected individuals over 70 years old and account for ~ 20% of COVID-19 deaths DO - 10.1126/sciimmunol.abl4340 ER -