%0 Generic
%A Vargas Alarcón, G.
%A Londoño, JD
%A Hernández Pacheco, G.
%A Burgos-Vargas,  R.
%8 2017-10-25
%U http://hdl.handle.net/10818/64208
%X Objective: To investigate the role of HLA-B and HLA-DR genes as contributors to genetic susceptibility and clinical expression of the spondyloarthropathies (SpA) in the Mexican population.  Methods: The study included 172 patients with SpA (undifferentiated SpA 83, ankylosing spondylitis (AS) 64, and reactive arthritis 25) and 99 healthy controls. The HLA-B and HLA-DR alleles were detected by the polymerase chain reaction with sequence-specific primers technique. Patient assessment included demographic data, diagnostic categories, and disease patterns. Statistical methods included the Mantel-Haenzel χ2 test, Fisher's exact test, and Woolf method for odds ratio (OR). Differences of continuous variables between HLA allele groups were calculated by Student's t test.
%I Anales de las Enfermedades Reumáticas
%T Effect of HLA-B and HLA-DR genes on susceptibility to and severity of spondyloarthropathies in Mexican patients
%T Efecto de los genes HLA-B y HLA-DR sobre la susceptibilidad y severidad de las espondiloartropatías en pacientes mexicanos
%R 10.1136/ard.61.8.714
%~ Intellectum