%0 Generic
%A Citarella B.W
%A Kartsonaki C
%A Ibáñez-Prada E.D
%A Gonçalves B.P
%A Baruch J
%A Escher M
%A Pritchard M.G
%A Wei J
%A Philippy F
%A Dagens A
%A Hall M
%A Lee J
%A Kutsogiannis D.J
%A Wils E.-J
%A Fernandes M.A
%A Tirupakuzhi Vijayaraghavan B.K
%A Panda P.K
%A Martin-Loeches I
%A Ohshimo S.
%8 2024
%@ 24058440
%U http://hdl.handle.net/10818/61983
%X Background: COVID-19 is primarily known as a respiratory illness; however, many patients present to hospital without respiratory symptoms. The association between non-respiratory presentations of COVID-19 and outcomes remains unclear. We investigated risk factors and clinical outcomes in patients with no respiratory symptoms (NRS) and respiratory symptoms (RS) at hospital admission. Methods: This study describes clinical features, physiological parameters, and outcomes of hospitalised COVID-19 patients, stratified by the presence or absence of respiratory symptoms at hospital admission. RS patients had one or more of: cough, shortness of breath, sore throat, runny nose or wheezing; while NRS patients did not. Results: Of 178,640 patients in the study, 86.4 % presented with RS, while 13.6 % had NRS. NRS patients were older (median age: NRS: 74 vs RS: 65) and less likely to be admitted to the ICU (NRS: 36.7 % vs RS: 37.5 %). NRS patients had a higher crude in-hospital case-fatality ratio (NRS 41.1 % vs. RS 32.0 %), but a lower risk of death after adjusting for confounders (HR 0.88 [0.83–0.93]). Conclusion: Approximately one in seven COVID-19 patients presented at hospital admission without respiratory symptoms. These patients were older, had lower ICU admission rates, and had a lower risk of in-hospital mortality after adjusting for confounders. © 2024 The Authors
%I Heliyon
%T Characteristics and outcomes of COVID-19 patients admitted to hospital with and without respiratory symptoms
%R 10.1016/j.heliyon.2024.e29591
%~ Intellectum