%0 Generic
%A García-Silva J
%A Ulloa-Gutierrez R
%A Ivankovich-Escoto G
%A Yamazaki-Nakashimada M.A
%A Faugier-Fuentes E
%A del Águila O
%A Camacho-Moreno G
%A Estripeaut D
%A Gutiérrez I.F
%A Castillo-Bustamante D
%A Luciani K
%A Fabi M
%A Espada G
%A Álvarez-Olmos M.I
%A Silfa C
%A Pérez-Camacho P
%A Duarte-Passos S
%A Cervi M.C
%A Martínez-Ramírez R.O
%A Cantillano E.M
%A Llamas-Guillén B.A
%A Velásquez-Méndez M
%A Saltigeral-Simental P
%A Criales J
%A Fernández-Sarmiento J
%A Chacon-Cruz E
%A García-Domínguez M
%A Aguilar K.L.B
%A Villarreal-Treviño A.V
%A Tremoulet A.H.
%8 2024
%@ 27727076
%U http://hdl.handle.net/10818/61895
%X Objectives: Our aim was to describe the epidemiology and outcomes of multisystem inflammatory syndrome in children (MIS-C) in Latin America. Methods: We conducted an observational, retrospective, and prospective multicenter study that gathered information from 84 participating centers across 16 Latin American countries between August 1, 2020 and June 30, 2022. Results: Of the 1239 reported children with MIS-C, 84.18% were previously healthy. The most frequent clinical manifestation in our studied population was abdominal pain (N = 804, 64.9%), followed by conjunctival injection (N = 784, 63.3%). The median duration of fever at the time of hospital admission was 5 days and a significant number of subjects required admission to an intensive care unit (N = 589, 47.5%). Most of the subjects (N = 1096, 88.7%) were treated with intravenous immunoglobulin, whereas 76.7% (N = 947) were treated with steroids, of whom 10.6% (N = 100) did not receive intravenous immunoglobulin. The death rate attributed to MIS-C was 4.88%, with a rate of 3.39% for those initially diagnosed with MIS-C and 8.85% for those whose admission diagnosis was not MIS-C (P <0.001, odds ratio 2.76, 95% confidence interval 1.6-4.6). Conclusions: One of the most significant findings from our study was the death rate, especially in those not initially diagnosed with MIS-C, in whom the rate was higher. This highlights the importance of increasing awareness and making an earlier diagnosis of MIS-C in Latin America. © 2024 The Author(s)
%I IJID Regions
%T Multisystem inflammatory syndrome in children across 16 Latin American countries: A multicenter study from the REKAMLATINA Network
%R 10.1016/j.ijregi.2024.100419
%~ Intellectum