%0 Generic
%A Serna I.
%A Cabezas L.
%A Caraballo S.B.
%A Quintero E.T.
%A Mantilla Y.
%A Guette D.O.
%A Collazos E.
%A Melendez D.C.V.
%A Barrero A.V.M.
%A León S.R.
%8 2023
%U http://hdl.handle.net/10818/59856
%X Introduction: Histoplasmosis is caused by the dimorphic fungus Histoplasma capsulatum, whose clinical manifestations range from asymptomatic to disseminated and highly fatal disease. Objective: To present the case of a patient diagnosed with disseminated histoplasmosis and SARS-CoV-2 infection. Clinical case: The case of a 79-year-old man is presented with a history of systemic arterial hypertension and type 2 diabetes mellitus. He was admitted for a week with nonproductive cough, dyspnea, and fatigue on moderate exertion, and reported having a positive antigen test for SARS-CoV-2. During hospitalization, he presented clinical deterioration, needing mechanical ventilation due to respiratory infection associated with COVID-19. Despite this, he presented lymphadenopathy, hepatosplenomegaly, and umbilicated skin-colored papules suggestive of disseminated fungal infection. Suspecting co-infection, infection by Histoplasma capsulatum was confirmed by means of mini-bronchoalveolar lavage and antifungal treatment was initiated; however, the patient presented persistent clinical deterioration and died. Conclusion: Cases of co-infections with COVID-19 in patients without chronic diseases or immunosuppressive states are rare, their diagnosis being a challenge for medical personnel and requiring consideration of pulmonary fungal infections such as cryptococcosis or histoplasmosis in associated respiratory failure. to SARS-CoV-2 infection. © 2023, Editorial Ciencias Medicas. All rights reserved.
%I Revista Cubana de Medicina Militar
%T Histoplasmosis and SARS-CoV-2 infection in a critically ill patient
%T Histoplasmosis e infección por SARS-CoV-2 en un paciente críticamente enfermo
%~ Intellectum