%0 Generic
%A Reyes, Luis F.
%A Bastidas Goyes, Alirio
%A Tuta Quintero, Eduardo Andrés
%A Pedreros, Karen D.
%A Mantilla, Yesid F.
%A Herrera, Manuela
%A Carmona, Germán A.
%A Saza, Laura D.
%A Pineda, Andrés F.
%8 2022
%@ 2052-4439
%U http://hdl.handle.net/10818/54580
%X Background The ROX index (Respiratory rate-OXygenation) has been described as a prediction tool to identify the need for invasive mechanical ventilation (IMV) in community-acquired pneumonia (CAP) with acute hypoxaemic respiratory failure treated with high-flow nasal cannula in order to avoid delay of a necessary intubation. However, its use in predicting the need for ventilatory support in hospitalised patients with CAP has not been validated.  Methods This is a retrospective cohort study including subjects with CAP treated in the general ward, emergency service or intensive care unit of a third-level centre in Cundinamarca, Colombia, between January 2001 and February 2020. The ROX index was estimated as the ratio of oxygen saturation/fraction of inspired oxygen to respiratory rate.  Results A total of 895 patients were included, of whom 93 (10%) required IMV. The ROX index proved to be a good predictor, presenting an area under the curve of receiver operating characteristics (AUROC) of 0.733 (95% CI 0.671 to 0.795, p<0.001) when determined by pulse oximetry and an AUROC of 0.779 (95% CI 0.699 to 0.859, p<0.001) when estimated by arterial blood gas (ABG) parameters, with an intraclass correlation of 0.894. The estimated cut-off point was 14.8; a score less than 14.8 indicates high risk of requiring IMV.  Conclusion The ROX index is a good predictor of IMV in hospitalised patients with CAP. It presents good performance when calculated through pulse oximetry and can replace the one calculated by ABG.
%I BMJ Open Respiratory Research
%T Validity of the ROX index in predicting invasive mechanical ventilation requirement in pneumonia
%R 10.1136/bmjresp-2022-001320
%~ Intellectum