%0 Journal Article
%A Santos, Ana M.
%A Peña, Paola
%A Avila, Mabel
%A Briceño Balcázar, Ignacio
%A Jaramillo, Carlos A.
%A Vargas Alarcon, Gilberto
%A Rueda, Juan C.
%A Saldarriaga, Eugenia Lucia
%A Angarita, Jose Ignacio
%A Martinez Rodriguez, Nancy
%A Londoño Patiño, John Darío
%8 2016-12-24
%U http://hdl.handle.net/10818/41342
%X There is substantial evidence that non-B27 major
histocompatibility complex (MHC) genes are associated with
spondyloarthritis (SpA). Studies in Mexican and Tunisian
populations demonstrated the association of SpA and human
leukocyte antigen (HLA) B15. The purpose of this study was
to evaluate the association of HLA-A, B, and DR antigens in a
group of Colombian patients with a diagnosis of SpA. A total
of 189 patients and 100 healthy subjects were included in the
present study. All subjects underwent a complete characterization of HLA alleles A, B, and DR. Of the 189 studied patients, 35 were reactive arthritis (ReA), 87 were ankylosing
spondylitis (AS), and 67 undifferentiated SpA (uSpA).
According to the Assessment of Spondyloarthritis
International Society (ASAS) criteria, 167 were axial SpA
(axSpA) and 171 were peripheral SpA (pSpA). 63.8% were
men, with a mean age of 35.9 ± 12.7 years. 40.7% (77/189) of
patients were HLA-B27 positive of which 52.9% had AS and
42.5% axSpA. 23.2% (44/189) of patients were HLA-B15
positive: 23.8% were uSpA, 12.57% were axSpA, and
11.7% were pSpA. In addition, HLA-DRB1*01 was
associated with AS (58.6%) and axSpA (42.5%). Also,
HLA-DRB1*04 was present in 62 patients with AS (71.2%)
and in 26 with axSpA (15.5%). In this population, we found a
strong association between the presence of HLA-B27 and the
diagnosis of axSpA and AS, but the HLA-B15 is also significantly associated with all subtypes of the disease, predominantly with pSpA. Additionally, HLA-DR1 and DR4 were
associated in a cohort of patients with SpA from Colombia.
%I Clinical Rheumatology
%K Allele frequency
%K Colombia
%K Genetics
%K HLA-B15
%K Humans
%K Spondyloarthritis
%T Association of human leukocyte A, B, and DR antigens in Colombian patients with diagnosis of spondyloarthritis
%R 10.1007 / s10067-016-3516-2
%~ Intellectum