%0 Journal Article
%A Vargas M.
%A Bustamante C.
%A Villarraga E.
%8 2015
%@ 0975-0851
%U http://hdl.handle.net/10818/36914
%X This is a pharmacokinetic study of two formulations containing Rosuvastatin 40 mg, with the aim to compare
the Bioavailability between the Test product (Rosuvastatin made by Laboratorios Tecnoquímicas S.A., Colombia)
and the Reference product (Crestor® made by Laboratorios AstraZeneca) in order to declare the Bioequivalence
between both formulations. For this, an open-label, two period and two sequences previously randomized, crossover
study in 30 healthy volunteers was developed, with a single 40 mg dose in fasting conditions, a washout period of 7
days and 14 plasma samples collection between 0 and 48 hours. For the identification and assessment of plasma
Rosuvastatin, an ultra-high performance liquid chromatography coupled to tandem mass spectrometer, UHPLC MS/
MS was the analytical method performed.
%I Journal of J Bioequivalence & Bioavailability
%K Bioequivalence
%K Rosuvastatin
%K Cholesterol
%K Statin
%K Pharmacokinetic
%T Bioequivalence Study of Two Formulations Containing Rosuvastatin 40 Mg Tablets in Healthy Colombians
%R 10.4172/jbb.1000245
%~ Intellectum