%0 Journal Article
%A Romero Sánchez, C.
%A Londoño Patiño, John Darío
%A Delgado, G.
%A Jaimes Fernández, Diego Alejandro
%A Mora Saboyá, Eduardo Alfonso
%A Ávila Portillo, Luz Mabel
%A Castellanos, J.
%A Valle Oñate, R.
%A Briceño Balcázar, Ignacio
%8 2011
%U http://hdl.handle.net/10818/33353
%X The pathogenesis of SpA is considered to be a
complex and multi-factorial process and, similar to other
autoimmune diseases, includes the activity of proinflammatory
cytokines such as TNF alpha. Our study compared
the -308 promoter polymorphism of TNF alpha with TNF
alpha levels, HLA-B27 status, age at the onset of symptoms,
SpA subtype and the clinical degree of activity in
Colombian SpA patients and healthy subjects (HS). Comparisons
of the TNF alpha-308A genotype among HS and
SpA patients (P = 0.004), uSpA patients (P = 0.040),
ReA patients (P = 0.001), were significantly different and
AS patients (P = 0.110), as were alleles for SpAs
(P = 0.007) between patients with SpAs and controls.
Initial exploratory analyses demonstrated that the TNF
alpha-308 SNP genotype frequencies were different among
SpA patients and HS in the Colombian population studied.
Furthermore, there was no significant correlation with
activity and functional clinical index, serum TNF alpha
level or HLA B27 status. Allele frequencies, on the other
hand, were correlated with the activity clinical index.
%I JCR Journal of Clinical Rheumatology
%K TNF Alpha
%K Polymorphism
%K Spondyloarthritides
%T Association of tumor necrosis factor alpha-308 promoter polymorphism with spondyloarthritides patients in Colombia
%R 10.1007/s00296-011-1883-1
%~ Intellectum