%0 Journal Article
%A Mier Giraldo, Helen
%A Díaz Barrera, Luis Eduardo
%A Delgado Murcia, Lucy Gabriela
%A Valero Valdivieso, Manuel Fernando
%A Cáez Ramírez, Gabriela Rabe
%8 2017-05-23
%U http://hdl.handle.net/10818/33130
%X It was purposed to evaluate the biological potential of ethanol and isopropanol crude extracts of ripe Physalis peruviana fruits.
Cytotoxic and immunomodulatory effects of the expression of interleukin-6, interleukin-8, and monocyte chemoattractant
protein-1 (MCP-1) were evaluated on human cervical cancer (HeLa) and murine fibroblast (L929) cells. The composition was
evaluated by high-performance liquid chromatography diode-array detection and high-performance liquid chromatography
ultraviolet/visible detection. The presence of ursolic acid and rosmarinic acid was found in both solvents. However, gallic acid,
quercetin, and epicatechin were higher in isopropanol extracts (P < .05). The results indicated a relationship among the total
polyphenol content, antioxidant activity, and cytotoxic activity that was dependent on the solvent used. Isopropanol extracts
presented a half-maximal inhibition concentration value (IC50) of 60.48 + 3.8 mg/mL for HeLa cells and 66.62 + 2.67 mg/mL for
L929 fibroblasts. The extracts reduced the release of interleukin-6, interleukin-8, and MCP-1 in a dose-dependent manner.
Extracts showed anticancer and immunomodulatory potential for new complementary pharmaceutical products development.
%I Journal of Evidence-Based Complementary & Alternative Medicine
%K Cytotoxicity
%K Immunomodulatory
%K Antioxidants
%T Cytotoxic and Immunomodulatory Potential Activity of Physalis peruviana Fruit Extracts on Cervical Cancer (HeLa) and Fibroblast (L929) Cells
%R 10.1177/2156587217718751
%~ Intellectum