@misc{10818/61895,
year = {2024},
url = {http://hdl.handle.net/10818/61895},
abstract = {Objectives: Our aim was to describe the epidemiology and outcomes of multisystem inflammatory syndrome in children (MIS-C) in Latin America. Methods: We conducted an observational, retrospective, and prospective multicenter study that gathered information from 84 participating centers across 16 Latin American countries between August 1, 2020 and June 30, 2022. Results: Of the 1239 reported children with MIS-C, 84.18% were previously healthy. The most frequent clinical manifestation in our studied population was abdominal pain (N = 804, 64.9%), followed by conjunctival injection (N = 784, 63.3%). The median duration of fever at the time of hospital admission was 5 days and a significant number of subjects required admission to an intensive care unit (N = 589, 47.5%). Most of the subjects (N = 1096, 88.7%) were treated with intravenous immunoglobulin, whereas 76.7% (N = 947) were treated with steroids, of whom 10.6% (N = 100) did not receive intravenous immunoglobulin. The death rate attributed to MIS-C was 4.88%, with a rate of 3.39% for those initially diagnosed with MIS-C and 8.85% for those whose admission diagnosis was not MIS-C (P <0.001, odds ratio 2.76, 95% confidence interval 1.6-4.6). Conclusions: One of the most significant findings from our study was the death rate, especially in those not initially diagnosed with MIS-C, in whom the rate was higher. This highlights the importance of increasing awareness and making an earlier diagnosis of MIS-C in Latin America. © 2024 The Author(s)},
publisher = {IJID Regions},
title = {Multisystem inflammatory syndrome in children across 16 Latin American countries: A multicenter study from the REKAMLATINA Network},
doi = {10.1016/j.ijregi.2024.100419},
author = {García-Silva J and Ulloa-Gutierrez R and Ivankovich-Escoto G and Yamazaki-Nakashimada M.A and Faugier-Fuentes E and del Águila O and Camacho-Moreno G and Estripeaut D and Gutiérrez I.F and Castillo-Bustamante D and Luciani K and Fabi M and Espada G and Álvarez-Olmos M.I and Silfa C and Pérez-Camacho P and Duarte-Passos S and Cervi M.C and Martínez-Ramírez R.O and Cantillano E.M and Llamas-Guillén B.A and Velásquez-Méndez M and Saltigeral-Simental P and Criales J and Fernández-Sarmiento J and Chacon-Cruz E and García-Domínguez M and Aguilar K.L.B and Villarreal-Treviño A.V and Tremoulet A.H.},
}