@misc{10818/61876,
year = {2024},
url = {http://hdl.handle.net/10818/61876},
abstract = {Background: Long-term health outcomes in children and young people (CYP) after COVID-19 infection are not well understood and studies with control groups exposed to other infections are lacking. This study aimed to investigate the incidence of post-COVID-19 condition (PCC) and incomplete recovery in CYP after hospital discharge and compare outcomes between different SARS-CoV-2 variants and non-SARS-CoV-2 infections. Methods: A prospective exposure-stratified cohort study of individuals under 18 years old in Moscow, Russia. Exposed cohorts were paediatric patients admitted with laboratory-confirmed COVID-19 infection between April 2 and December 11, 2020 (Wuhan variant cohort) and between January 12 and February 19, 2022 (Omicron variant cohort). CYP admitted with respiratory and intestinal infections, but negative lateral flow rapid diagnostic test and PCR-test results for SARS-CoV-2, between January 12 and February 19, 2022, served as unexposed reference cohort. Comparison between the ‘exposed cohorts’ and ‘reference cohort’ was conducted using 1:1 matching by age and sex. Follow-up data were collected via telephone interviews with parents, utilising the long COVID paediatric protocol and survey developed by the International Severe Acute Respiratory and Emerging Infection Consortium (ISARIC). The WHO case definition was used to categorise PCC. Results: Of 2595 CYP with confirmed COVID-19, 1707 (65.7%) participated in follow-up interviews, with 1183/1707 (69%) included in the final ‘matched’ analysis. The median follow-up time post-discharge was 6.7 months. The incidence of PCC was significantly higher in the Wuhan variant cohort (89.7 cases per 1000 person-months, 95% CI 64.3–120.3) compared to post-infection sequalae in the reference cohort (12.2 cases per 1000 person-months, 95% CI 4.9–21.9), whereas the difference with the Omicron variant cohort and reference cohort was not significant. The Wuhan cohort had higher incidence rates of dermatological, fatigue, gastrointestinal, sensory, and sleep manifestations, as well as behavioural and emotional problems than the reference cohort. The only significant difference between Omicron variant cohort and reference cohort was decreased school attendance. When comparing the Wuhan and Omicron variant cohorts, higher incidence of PCC and event rates of fatigue, decreased physical activity, and deterioration of relationships was observed. The rate of incomplete recovery was also significantly higher in the Wuhan variant cohort than in both the reference and the Omicron variant cohorts. Conclusions: Wuhan variant exhibited a propensity for inducing a broad spectrum of physical symptoms and emotional behavioural changes, suggesting a pronounced impact on long-term health outcomes. Conversely, the Omicron variant resulted in fewer post-infection effects no different from common seasonal viral illnesses. This may mean that the Omicron variant and subsequent variants might not lead to the same level of long-term health consequences as earlier variants. © 2024, The Author(s).},
publisher = {BMC Medicine},
title = {Event rates and incidence of post-COVID-19 condition in hospitalised SARS-CoV-2 positive children and young people and controls across different pandemic waves: exposure-stratified prospective cohort study in Moscow (StopCOVID)},
doi = {10.1186/s12916-023-03221-x},
author = {Pazukhina E and Rumyantsev M and Baimukhambetova D and Bondarenko E and Markina N and El-Taravi Y and Petrova P and Ezhova A and Andreeva M and Iakovleva E and Bobkova P and Pikuza M and Trefilova A and Abdeeva E and Galiautdinova A and Filippova Y and Bairashevskaia A and Zolotarev A and Bulanov N and Dunngalvin A and Chernyavskaya A and Kondrikova E and Kolotilina A and Gadetskaya S and Ivanova Y.V and Turina I and Eremeeva A and Fedorova L.A and Comberiati P and Peroni D.G and Nekliudov N and Genuneit J and Reyes L.F and Brackel C.L.H and Mazankova L and Miroshina A and Samitova E and Borzakova S and Carson G and Sigfrid L and Scott J.T and McFarland S and Greenhawt M and Buonsenso D and Semple M.G and Warner J.O and Olliaro P and Osmanov I.M and Korsunskiy A.A and Munblit D and Aktulaeva K and Aldanov I and Alekseeva N and Assanova R and Avagyan A and Babkova I and Baziyants L and Berbenyuk A and Bezbabicheva T and Chayka J and Cherdantseva I and Chervyakova Y and Chitanava T and Chubukov A and Degtiareva N and Demyanov G and Demyanov S and Deunezhewa S and Dubinin A and Dymchishina A and Dzhavadov M and Edilgireeva L and Filippova V and Frumkina Y and Gorina A and Gorlenko C and Gripp M and Grosheva M and Gudratova E and Iakimenko E and Kalinina M and Kharchenko E and Kholstinina A and Kirillov B and Kiseljow H and Kogut N and Kondrashova P and Konova I and Korgunova M and Kotelnikova A and Krupina A and Kuznetsova A and Kuznetsova A and Kuznetsova A.S and Laevskaya A and Laukhina V and Lavginova B and Levina Y and Lidjieva E and Butorina A and Lyaginskaya J and Lyubimova E and Magomedov S and Mamchich D and Minazetdinova R and Mingazov A and Mursalova A and Nikolaeva D and Nikolenko A and Novikov V and Novoselov G and Ovchinnikova U and Palchikova V and Papko K and Pavlova M and Pecherkina A and Permyakova S and Porubayeva E and Presnyakova K and Privalov M and Prutkogliadova A and Pushkareva A and Redya A and Romanenko A and Roshchin F and Salakhova D and Sankova M and Sarukhanyan I and Savina V and Semeniako E and Seregina V and Shapovalova A and Sharbetova K and Shishkina N and Shvedova A and Stener V and Ustyan V and Valieva Y and Varaksina M and Varaksina K and Varlamova E and Vlasova N and Yegiyan M and Ziskina N and Zolochevskaya D and Zuykova E and Sechenov Stop COVID Research Team},
}