@misc{10818/54580,
year = {2022},
url = {http://hdl.handle.net/10818/54580},
abstract = {Background The ROX index (Respiratory rate-OXygenation) has been described as a prediction tool to identify the need for invasive mechanical ventilation (IMV) in community-acquired pneumonia (CAP) with acute hypoxaemic respiratory failure treated with high-flow nasal cannula in order to avoid delay of a necessary intubation. However, its use in predicting the need for ventilatory support in hospitalised patients with CAP has not been validated.  Methods This is a retrospective cohort study including subjects with CAP treated in the general ward, emergency service or intensive care unit of a third-level centre in Cundinamarca, Colombia, between January 2001 and February 2020. The ROX index was estimated as the ratio of oxygen saturation/fraction of inspired oxygen to respiratory rate.  Results A total of 895 patients were included, of whom 93 (10%) required IMV. The ROX index proved to be a good predictor, presenting an area under the curve of receiver operating characteristics (AUROC) of 0.733 (95% CI 0.671 to 0.795, p<0.001) when determined by pulse oximetry and an AUROC of 0.779 (95% CI 0.699 to 0.859, p<0.001) when estimated by arterial blood gas (ABG) parameters, with an intraclass correlation of 0.894. The estimated cut-off point was 14.8; a score less than 14.8 indicates high risk of requiring IMV.  Conclusion The ROX index is a good predictor of IMV in hospitalised patients with CAP. It presents good performance when calculated through pulse oximetry and can replace the one calculated by ABG.},
publisher = {BMJ Open Respiratory Research},
title = {Validity of the ROX index in predicting invasive mechanical ventilation requirement in pneumonia},
doi = {10.1136/bmjresp-2022-001320},
author = {Reyes, Luis F. and Bastidas Goyes, Alirio and Tuta Quintero, Eduardo Andrés and Pedreros, Karen D. and Mantilla, Yesid F. and Herrera, Manuela and Carmona, Germán A. and Saza, Laura D. and Pineda, Andrés F.},
}