@article{10818/37243,
year = {2010},
url = {http://hdl.handle.net/10818/37243},
abstract = {Objective. Fetal  goitrous  hypothyroidism  is  a  rare  and  potentially  lethal  condition.  Consequently,  itsearly diagnosis and treatment improve prognosis. Thyroid hormone measurement in either fetal serumor amniotic fluid implies important risks. Here we present a fetal goiter and the follow-up procedure,both done by the traditional method and by using 3-dimensional power Doppler (3DPD) imaging andvirtual organ computer-aided analysis (VOCAL). Methods.A single well-documented case of fetal goi-ter  was  followed  weekly  from  22  weeks  until  delivery.  Amniocentesis  for  thyrotropin  (TSH)  and  freethyroxine  (T4)  measurement  as  well  as  levothyroxine  injections  were  performed  at  every  control.  Inaddition to amniocentesis, every control involved a sonographic evaluation, which included standardmeasurements of the gland and the capture of volume image sets in gray scale and 3DPD. Volume cal-culation of the gland was done using VOCAL software. Vascularization of the gland was evaluated bythe vascularization index (VI) included in the software. Results. With treatment, TSH levels decreasedprogressively  until  normalization.  Free  T4levels  increased  toward  the  end  of  gestation.  Sonographicmeasurements of the gland volume to estimated fetal weight ratio decreased across treatment as lev-els  of  TSH  did.  The  VI  clearly  depicted  the  vascular  regression  of  the  goiter,  decreasing  throughouttreatment in a consistent way until 24 hours before delivery. Conclusions.Gray scale and 3DPD eval-uations  of  the  thyroid  gland  have  been  validated  under  similar  circumstances  and  might  be  reliablecomplements to the invasive methods used in the management of this fetal condition. Key words:fetal  hypothyroidism;  goiter;  3-dimensional  power  Doppler  sonography;  3-dimensional  sonography;virtual organ computer-aided analysis.},
publisher = {Journal of Ultrasound in Medicine},
title = {Use of 3‐Dimensional Sonography for Prenatal Evaluation and Follow‐up of Fetal Goitrous Hypothyroidism},
doi = {10.7863/jum.2010.29.9.1339},
author = {Cuevas Marín, Rodrigo and Bello Muñoz, Juan Carlos and Villagómez Martínez, Gabriel and Arévalo Martínez, Silvia and Carreras Moratonas, Elena and Cabero Roura, Lluis},
}