@misc{10818/33027,
year = {2017},
url = {http://hdl.handle.net/10818/33027},
abstract = {Biological activities from
polyurethanes (PUs) synthesized from polyols (derived from castor oil) and isophorone diisocyanate were evaluated. In vitro
degradability was evaluated by phosphate buffered saline (PBS) and antibacterial degradation with Escherichia coli and Pseudomonas
aeruginosa. The biocompatibility was analyzed by: i) the antimicrobial activity against E. coli, S. aureus and P. aeruginosa, and ii) in
vitro cytotoxicity assays using mouse embryonic fibroblast cell line L-929 in direct contact with the PUs and with NIH/3T3 cells in
indirect contact with the PUs degradation products. PUs with polyol P1 (2,64% molar relation of pentaerythritol and castor oil) was
the material with better biodegradation properties: 1.125±0.110% in 72 h by PBS at 100 °C. In general, all materials were degraded
up to 1.000±0.223% and 2.251±0.010% in 72 h by E. coli and P. aeruginosa, respectively. On the other hand, it was determined a
close relationship between functionality of polyol and bacterial inhibition. The antibacterial effect of the PUs decreased by 67% for
E. coli, 55% for S. aureus and 56% for P. aeruginosa after 24 h. Chemical modification of castor oil did not generate a cytotoxic effect
on the tested cell lines. The evaluated materials are suggested as candidates to obtain biomaterials due to their mechanical properties
and biocompatibility presented in untransformed cells.},
publisher = {Química Nova},
keywords = {Castor oil},
keywords = {Polycaprolactone},
keywords = {Cytotoxicity},
keywords = {Degradability},
keywords = {Biomedical applications},
title = {Actividad antibacteriana, degradación hidrolítica y microbiana y citotoxicidad in vitro de poliuretanos sintetizados con polioles derivados del aceite de higuerilla},
doi = {10.21577/0100-4042.20160172},
author = {Uscategui, Yomaira L. and Díaz Barrera, Luis Eduardo and Valero Valdivieso, Manuel Fernando},
}