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dc.contributor.authorSalas Hernández A.
dc.contributor.authorGalleguillos M.
dc.contributor.authorCarrasco M.
dc.contributor.authorLópez Cortés A.
dc.contributor.authorRedal M.A.
dc.contributor.authorFonseca Mendoza D.
dc.contributor.authorEsperón P.
dc.contributor.authorGonzález Martínez F.
dc.contributor.authorLares Asseff I.
dc.contributor.authorLazarowski A.
dc.contributor.authorLoera Castañeda V.
dc.contributor.authorRemírez D.
dc.contributor.authorMartínez M.F.
dc.contributor.authorVargas R.
dc.contributor.authorRios Santos F.
dc.contributor.authorMacho A.
dc.contributor.authorCayún J.P.
dc.contributor.authorPerez G.R.
dc.contributor.authorGutierrez C.
dc.contributor.authorCerpa L.C.
dc.contributor.authorLeiva T.
dc.contributor.authorCalfunao S.
dc.contributor.authorXajil L.
dc.contributor.authorSandoval C.
dc.contributor.authorSuárez M.
dc.contributor.authorGonzalez A.
dc.contributor.authorEcheverría Garcés G.
dc.contributor.authorSullón Dextre L.
dc.contributor.authorCordero García E.
dc.contributor.authorMorales A.R.
dc.contributor.authorAvendaño A.
dc.contributor.authorSánchez E.
dc.contributor.authorBastone L.C.
dc.contributor.authorLara C.
dc.contributor.authorZuluaga Arias P.
dc.contributor.authorSoler A.M.
dc.contributor.authorDa Luz J.
dc.contributor.authorBurgueño Rodríguez G.
dc.contributor.authorVital M.
dc.contributor.authorReyes Reyes E.
dc.contributor.authorHuaccha A.
dc.contributor.authorAriza Y.V.
dc.contributor.authorTzul N.
dc.contributor.authorRendón A.L.
dc.contributor.authorSerrano R.
dc.contributor.authorAcosta L.
dc.contributor.authorMotta Pardo A.
dc.contributor.authorBeltrán Angarita L.
dc.contributor.authorBrand E.
dc.contributor.authorJiménez M.A.
dc.contributor.authorHidalgo Lozada G.M.
dc.contributor.authorRomero Prado M.M.J.
dc.contributor.authorEscobar Castro K.
dc.contributor.authorUmaña Rivas M.
dc.contributor.authorVivas J.D.
dc.contributor.authorLagos P.
dc.contributor.authorMartínez Y.B.
dc.contributor.authorQuesada S.
dc.contributor.authorCalfio C.
dc.contributor.authorArias M.L.
dc.contributor.authorLavanderos M.A.
dc.contributor.authorCáceres D.D.
dc.contributor.authorSalazar Granara A.
dc.contributor.authorVarela N.M.
dc.contributor.authorQuiñones L.A.
dc.date.accessioned2024-04-19T15:53:01Z
dc.date.available2024-04-19T15:53:01Z
dc.date.issued2023
dc.identifier.citationSalas-Hernández, A., Galleguillos, M., Carrasco, M., López-Cortés, A., Redal, M.A., Fonseca-Mendoza, D., Esperón, P., González-Martínez, F., Lares-Asseff, I., Lazarowski, A., Loera-Castañeda, V., Remírez, D., Martínez, M.F., Vargas, R., Rios-Santos, F., Macho, A., Cayún, J.P., Perez, G.R., Gutierrez, C., Cerpa, L.C., Leiva, T., Calfunao, S., Xajil, L., Sandoval, C., Suárez, M., Gonzalez, A., Echeverría-Garcés, G., Sullón-Dextre, L., Cordero-García, E., Morales, A.R., Avendaño, A., Sánchez, E., Bastone, L.C., Lara, C., Zuluaga-Arias, P., Soler, A.M., Da Luz, J., Burgueño-Rodríguez, G., Vital, M., Reyes-Reyes, E., Huaccha, A., Ariza, Y.V., Tzul, N., Rendón, A.L., Serrano, R., Acosta, L., Motta-Pardo, A., Beltrán-Angarita, L., Brand, E., Jiménez, M.A., Hidalgo-Lozada, G.M., Romero-Prado, M.M.J., Escobar-Castro, K., Umaña-Rivas, M., Vivas, J.D., Lagos, P., Martínez, Y.B., Quesada, S., Calfio, C., Arias, M.L., Lavanderos, M.A., Cáceres, D.D., Salazar-Granara, A., Varela, N.M., Quiñones, L.A., On behalf of the RELIVAF NETWORK An updated examination of the perception of barriers for pharmacogenomics implementation and the usefulness of drug/gene pairs in Latin America and the Caribbean (2023) Frontiers in Pharmacology, 14, art. no. 1175737es_CO
dc.identifier.otherhttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85160413883&doi=10.3389%2ffphar.2023.1175737&partnerID=40&md5=8977667d2290b8f684added715ec87b3
dc.identifier.urihttp://hdl.handle.net/10818/59850
dc.description.abstractPharmacogenomics (PGx) is considered an emergent field in developing countries. Research on PGx in the Latin American and the Caribbean (LAC) region remains scarce, with limited information in some populations. Thus, extrapolations are complicated, especially in mixed populations. In this paper, we reviewed and analyzed pharmacogenomic knowledge among the LAC scientific and clinical community and examined barriers to clinical application. We performed a search for publications and clinical trials in the field worldwide and evaluated the contribution of LAC. Next, we conducted a regional structured survey that evaluated a list of 14 potential barriers to the clinical implementation of biomarkers based on their importance. In addition, a paired list of 54 genes/drugs was analyzed to determine an association between biomarkers and response to genomic medicine. This survey was compared to a previous survey performed in 2014 to assess progress in the region. The search results indicated that Latin American and Caribbean countries have contributed 3.44% of the total publications and 2.45% of the PGx-related clinical trials worldwide thus far. A total of 106 professionals from 17 countries answered the survey. Six major groups of barriers were identified. Despite the region’s continuous efforts in the last decade, the primary barrier to PGx implementation in LAC remains the same, the “need for guidelines, processes, and protocols for the clinical application of pharmacogenetics/pharmacogenomics”. Cost-effectiveness issues are considered critical factors in the region. Items related to the reluctance of clinicians are currently less relevant. Based on the survey results, the highest ranked (96%–99%) gene/drug pairs perceived as important were CYP2D6/tamoxifen, CYP3A5/tacrolimus, CYP2D6/opioids, DPYD/fluoropyrimidines, TMPT/thiopurines, CYP2D6/tricyclic antidepressants, CYP2C19/tricyclic antidepressants, NUDT15/thiopurines, CYP2B6/efavirenz, and CYP2C19/clopidogrel. In conclusion, although the global contribution of LAC countries remains low in the PGx field, a relevant improvement has been observed in the region. The perception of the usefulness of PGx tests in biomedical community has drastically changed, raising awareness among physicians, which suggests a promising future in the clinical applications of PGx in LAC.en
dc.language.isoenges_CO
dc.publisherFrontiers in Pharmacologyes_CO
dc.relation.ispartofseriesFrontiers in Pharmacology 14, 1175737
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.sourceUniversidad de La Sabanaes_CO
dc.sourceIntellectum Repositorio Universidad de La Sabanaes_CO
dc.subject.other6 Mercaptopurine derivativeen
dc.subject.otherBiological markeren
dc.subject.otherClopidogrelen
dc.subject.otherCytochrome P450 2c19en
dc.subject.otherCytochrome P450 2d6en
dc.subject.otherCytochrome P450 3a5en
dc.subject.otherDrugen
dc.subject.otherEfavirenzen
dc.subject.otherFluoropyrimidine derivativeen
dc.titleAn updated examination of the perception of barriers for pharmacogenomics implementation and the usefulness of drug/gene pairs in Latin America and the Caribbeanen
dc.typejournal articlees_CO
dc.type.hasVersionpublishedVersiones_CO
dc.rights.accessRightsopenAccesses_CO
dc.identifier.doi10.3389/fphar.2023.1175737


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