Desempeño del índice Corb (confusión, oxigenación, frecuencia respiratoria, y presión arterial) como puntaje alternativo para la predicción de complicaciones en neumonía

Frías Ordoñez, Juan Sebastián; Aguilar Chacón, Álvaro Fernando

dc.contributor.advisor	Bastidas Goyes, Alirio Rodrigo
dc.contributor.advisor	Reyes Velasco, Luis Felipe
dc.contributor.advisor	Jaimes Mantilla, Anyelinne
dc.contributor.advisor	Ramírez Torra, Silvia Margarita
dc.contributor.author	Frías Ordoñez, Juan Sebastián
dc.contributor.author	Aguilar Chacón, Álvaro Fernando
dc.date.accessioned	2021-02-26T17:06:09Z
dc.date.available	2021-02-26T17:06:09Z
dc.date.issued	2021-02-08
dc.identifier.uri	http://hdl.handle.net/10818/46973
dc.description	97 páginas	es_CO
dc.description.abstract	Objetivo: Valorar el desempeño de la puntaje CORB en sujetos con neumonía adquirida en la comunidad (NAC) en relación a la predicción de muerte intrahospitalaria, muerte a 30 días, requerimiento de ventilación mecánica (VM) y soporte vasopresor. Metodología: Estudio de cohorte retrospectiva con análisis de prueba diagnóstica de los puntajes CORB (Confusión, oxigenación: SpO2 ≤ 90% o SpO2/FiO2<300, frecuencia respiratoria (FR), presión arterial) y CURB-65. Se consideró neumonía adquirida en la comunidad (NAC) según la definición ATS/IDSA, se calcularon los odds ratio crudos y ajustados de cada variable utilizada en la construcción de los puntajes con los desenlaces evaluados, y se construyeron las áreas bajo la curva ROC (ACOR), sensibilidad, especificidad, valor predictivo positivo y negativa, razón de verosimilitud positiva y negativa de cada una de las curvas con los desenlaces de muerte intrahospitalaria, muerte a 30 días, requerimiento de soporte vasopresor y requerimiento de ventilación mecánica.	es_CO
dc.description.abstract	Objective: To assess the performance of the CORB score in subjects with community-acquired pneumonia (CAP) in relation to the prediction of in-hospital death, death at 30 days, requirement of mechanical ventilation (MV) and vasopressor support. Materials and methods: Retrospective cohort study with analysis of CORB scores (Confusion, oxygenation: SpO2 ≤ 90% or SpO2 / FiO2 <300, respiratory rate (RR), blood pressure) and CURB-65. Community acquired pneumonia (CAP) was considered according to the ATS / IDSA definition, the crude and adjusted relative risks of each variable used in the construction of the scores with the evaluated outcomes were calculated, and the areas under the ROC curve (AUC), sensitivity, specificity, positive and negative predictive value, positive and negative likelihood ratio of each of the curves with the outcomes of in-hospital death, death at 30 days, requirement for vasopressor support and mechanical ventilation.	eng
dc.format	application/pdf	es_CO
dc.language.iso	spa	es_CO
dc.publisher	Universidad de La Sabana	es_CO
dc.rights	Attribution-NonCommercial-NoDerivatives 4.0 International	*
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/4.0/	*
dc.source	instname:Universidad de La Sabana	es_CO
dc.source	reponame:Intellectum Repositorio Universidad de La Sabana	es_CO
dc.title	Desempeño del índice Corb (confusión, oxigenación, frecuencia respiratoria, y presión arterial) como puntaje alternativo para la predicción de complicaciones en neumonía	es_CO
dc.type	bachelorThesis	es_CO
dc.identifier.local	280874
dc.identifier.local	TE11158
dc.type.hasVersion	publishedVersion	es_CO
dc.rights.accessRights	restrictedAccess	es_CO
dc.subject.armarc	Neumonía	spa
dc.subject.armarc	Unidades de cuidados intensivos	spa
dc.subject.armarc	Respiración artificial	spa
dc.subject.decs	Vasoconstrictores	spa
dc.subject.decs	Hipoxia	spa
dcterms.references	Heron M. Deaths: Leading causes for 2015. Natl Vital Stat Reports. 2017;66(5).	en
dcterms.references	WHO. Top ten causes of death. Top ten causes of death [Internet]. 2018;1– 8. Available from: https://www.who.int/news-room/fact-sheets/detail/the-top10-causes-of-death	en
dcterms.references	Ramirez JA, Wiemken TL, Peyrani P, Arnold FW, Kelley R, Mattingly WA, et al. Adults Hospitalized with Pneumonia in the United States: Incidence, Epidemiology, and Mortality. Clin Infect Dis. 2017;65(11):1806–12.	en
dcterms.references	Fine MJ, Auble TE , Yealy DM , Hanusa BH, Weissfeld LA , Singer DE , Coley CM , Marrie TJ KW. A predicition rule to indetify low-risk patients with community acquired pneumonia. N Engl J Med. 1997;336(4):243–50	en
dcterms.references	Lim WS, van der Eerden MM, Laing R, Boersma WG, Karalus N, Town GI, Lewis SA MJ. Defining community acquired pneumonia severity on presentation to hospital: An international derivation and validation study. Thorax. 2003;58(5):377–82	en
dcterms.references	Marti C, Garin N, Grosgurin O, Poncet A, Combescure C, Carballo S, et al. Prediction of severe community-acquired pneumonia: A systematic review and meta-analysis. Crit Care [Internet]. 2012;16(4):R141. Available from: http://ccforum.com/content/16/4/R141	en
dcterms.references	Woodhead M, Welch CA, Harrison DA, Bellingan G, Ayres JG. Communityacquired pneumonia on the intensive care unit: Secondary analysis of 17,869 cases in the ICNARC Case Mix Programme Database. Crit Care. 2006;10(SUPPL. 2).	en
dcterms.references	Restrepo MI, Mortensen EM, Rello J, Brody J, Anzueto A. Late admission to the ICU in patients with community-acquired pneumonia is associated with higher mortality. Chest. 2010;137(3):552–7.	en
dcterms.references	Buising KL, Thursky KA, Black JF, MacGregor L, Street AC, Kennedy MP, et al. A prospective comparison of severity scores for identifying patients with severe community acquired pneumonia: Reconsidering what is meant by severe pneumonia. Thorax. 2006;61(5):419–24.	en
dcterms.references	Quintana JM, Areitio I, Gorordo I, Capelastegui A, Espan PP, Egurrola M, et al. Validation of a predictive rule for the management of community-acquired pneumonia ˜. Eur Respir J. 2006;27:151–7.	en
dcterms.references	Metlay JP, Waterer GW, Long AC, Anzueto A, Brozek J, Crothers K, et al. Diagnosis and treatment of adults with community-acquired pneumonia. Am J Respir Crit Care Med. 2019;200(7):E45–67.	en
dcterms.references	Lim WS, Baudouin S, George R, Hill A, Jamieson C, Le Jeune I, et al. British Thoracic Society guidelines for the management of community acquired pneumonia in adults: Update 2009. Thorax. 2009;64(SUPPL. 3)	en
dcterms.references	Kalil AC, Metersky ML, Klompas M, Muscedere J, Sweeney DA, Palmer LB, et al. Management of Adults With Hospital-acquired and Ventilatorassociated Pneumonia: 2016 Clinical Practice Guidelines by the Infectious Diseases Society of America and the American Thoracic Society. Clin Infect Dis. 2016;63(5):e61–111.	en
dcterms.references	Torres A, Niederman MS, Chastre J, Ewig S, Fernandez-Vandellos P, Hanberger H, et al. International ERS/ESICM/ESCMID/ALAT guidelines for the management of hospital-acquired pneumonia and ventilator-associated pneumonia. Eur Respir J. 2017;50(3)	en
dcterms.references	Moreno Claudia RY. Analisis De Situación De Salud ( ASIS ) Dirección de Epidemiología y Demografía. Minist salud [Internet]. 2018;1–143. Available from: https://www.minsalud.gov.co/sites/rid/Lists/BibliotecaDigital/RIDE/VS/ED/PS P/asis-nacional-2017.pdf	es_CO
dcterms.references	Montufar FE, Varón FA, Sáenz OA. Infectio Asociación Colombiana de Infectología Recomendaciones para el diagnóstico , tratamiento y prevención de la neumonía adquirida en la comunidad en adultos Recommendations for diagnosis , treatment and prevention of communityacquired pneumonia in i. Infectio. 2013;17(Supl 1):1–38	es_CO
dcterms.references	Marrie TJ, Mapplsc JQH. Epidemiology of community-acquired pneumonia in Edmonton, Alberta. 2015;12(3):139–43.	en
dcterms.references	Medicare.gov - Hospital Compare..pdf.	en
dcterms.references	Alí, A, Ortiz, G, Dueñas C. Concenso Colombiano de neumonia nosocomial 2013. 2013;17(1):6–18.	es_CO
dcterms.references	Magill SS, O’Leary E, Janelle SJ, Thompson DL, Dumyati G, Nadle J, et al. Changes in prevalence of health care-associated infections in U.S. Hospitals. N Engl J Med. 2018;379(18):1732–44.	en
dcterms.references	Metersky ML, Wang Y, Klompas M, Eckenrode S, Bakullari A, Eldridge N. Trend in ventilator-associated pneumonia rates between 2005 and 2013. JAMA - J Am Med Assoc. 2016;316(22):2427–9.	en
dcterms.references	Wunderink RG, Waterer GW. Community-acquired pneumonia. N Engl J Med. 2014;370(6):543–51.	en
dcterms.references	Wang Y, Wang Y, Chen Y QQ. Unique epidemiological and clinical features of the emerging 2019 novel coronavirus pneumonia (COVID-19) implicate special control measures. J Med Virol. 2020;92:568– 576.	en
dcterms.references	Xie J, Covassin N, Fan Z, Singh P, Gao W, Li G, et al. Association Between Hypoxemia and Mortality in Patients With COVID-19. Mayo Clin Proc [Internet]. 2020;1–10. Available from: https://doi.org/10.1016/j.mayocp.2020.04.006	en
dcterms.references	Cillóniz C, Polverino E, Ewig S, Aliberti S, Gabarrús A, Menéndez R, et al. Impact of age and comorbidity on cause and outcome in community-acquired pneumonia. Chest. 2013;144(3):999–1007	en
dcterms.references	Torres A, Peetermans WE, Viegi G, Blasi F. Risk factors for communityacquired pneumonia in adults in Europe: A literature review. Thorax. 2013;68(11):1057–65.	en
dcterms.references	Ito A, Ishida T, Tokumasu H, Washio Y, Yamazaki A, Ito Y, et al. Prognostic factors in hospitalized community-acquired pneumonia: A retrospective study of a prospective observational cohort. BMC Pulm Med. 2017;17(1):1–10	en
dcterms.references	Li JS, Hou ZK, Yu XQ, Li SY, Sun ZK, Zhang W, et al. Prognostic factors for community-acquired pneumonia in middle-aged and elderly patients treated with integrated medicine. J Tradit Chinese Med [Internet]. 2012;32(2):179– 86. Available from: http://dx.doi.org/10.1016/S0254-6272(13)60008-4	en
dcterms.references	Zalacain R, Torres A, Celis R, Blanquer J, Aspa J, Esteban L, et al. Community-acquired pneumonia in the elderly: Spanish multicentre study. 57 Eur Respir J. 2003;21(2):294–302	en
dcterms.references	Waterer GW, Kessler LA, Wunderink RG. Delayed administration of antibiotics and atypical presentation in community-acquired pneumonia. Chest [Internet]. 2006;130(1):11–5. Available from: http://dx.doi.org/10.1378/chest.130.1.11	en
dcterms.references	Musher DM, Roig IL, Cazares G, Stager CE, Logan N, Safar H. Can an etiologic agent be identified in adults who are hospitalized for communityacquired pneumonia: Results of a one-year study. J Infect [Internet]. 2013;67(1):11–8. Available from: http://dx.doi.org/10.1016/j.jinf.2013.03.003	en
dcterms.references	Alves dos Santos JW, Torres A, Trindade Michel G, Cornelius de Figueiredo CW, Nascimento Mileto J, Gentil Foletto V, et al. Non-infectious and unusual infectious mimics of community-acquired pneumonia. Respir Med. 2004;98(6):488–94	en
dcterms.references	Cukic V, Hadzic A. The Most Common Detected Bacteria in Sputum of Patients with Community Acquired Pneumonia (CAP) Treated In Hospital. Med Arch (Sarajevo, Bosnia Herzegovina). 2016;70(5):354–8.	en
dcterms.references	Zhang D, Yang D, Makam AN. Utility of Blood Cultures in Pneumonia. Am J Med. 2019;132(10):1233–8.	en
dcterms.references	Baron EJ, Miller JM, Weinstein MP, Richter SS, Gilligan PH, Thomson RB, et al. A guide to utilization of the microbiology laboratory for diagnosis of infectious diseases: 2013 recommendations by the infectious diseases society of America (IDSA) and the American Society for Microbiology (ASM). Clin Infect Dis. 2013;57(4)	en
dcterms.references	Uematsu H, Hashimoto H, Iwamoto T, Horiguchi H, Yasunaga H. Impact of guideline-concordant microbiological testing on outcomes of pneumonia. Int J Qual Heal Care. 2014;26(1):100–7.	en
dcterms.references	Watkins RR, Lemonovich TL. Diagnosis and management of community acquired pneumonia in adults. Am Fam Physician. 2011;83(11):1299–306.	en
dcterms.references	Loeffelholz MJ, Tang YW. Laboratory diagnosis of emerging human coronavirus infections–the state of the art. Emerg Microbes Infect. 2020;9(1):747–56.	en
dcterms.references	Saavedra Trujillo CH. Resumen: Consenso colombiano de atención, diagnóstico y manejo de la infección por SARS-COV-2/COVID-19 en establecimientos de atención de la salud - Recomendaciones basadas en consenso de expertos e informadas en la evidencia. Infectio. 2020;24(3)	es_CO
dcterms.references	Chen H, Weng H, Lin M, He P, Li Y, Xie Q, et al. The Clinical Significance of FilmArray Respiratory Panel in Diagnosing Community-Acquired Pneumonia. Biomed Res Int. 2017;2017.	en
dcterms.references	Mandell LA, Wunderink RG, Anzueto A, Bartlett JG, Campbell GD, Dean NC, et al. Infectious Diseases Society of America/American Thoracic Society Consensus Guidelines on the Management of Community-Acquired Pneumonia in Adults. Clin Infect Dis. 2007;44(Supplement_2):S27–72.	en
dcterms.references	Lim WS, Van Der Eerden MM, Laing R, Boersma WG, Karalus N, Town GI, et al. Defining community acquired pneumonia severity on presentation to hospital: An international derivation and validation study. Thorax. 2003;58(5):377–82.	en
dcterms.references	Lim WS, Lewis S, Macfarlane JT. Severity prediction rules in community	en
dcterms.references	Lim WS, Macfarlane JT, Boswell TCJ, Harrison TG, Rose D, Leinonen M, et al. Study of community acquired pneumonia aetiology (SCAPA) in adults admitted to hospital: Implications for management guidelines. Thorax. 2001;56(4):296–301.	en
dcterms.references	Renaud B, Coma E, Labarere J, Hayon J, Roy P, Boureaux H, et al. Routine Use of the Pneumonia Severity Index for Guiding the Site‐of‐Treatment Decision of Patients with Pneumonia in the Emergency Department: A Multicenter, Prospective, Observational, Controlled Cohort Study. Clin Infect Dis. 2007;44(1):41–9.	en
dcterms.references	Gonzalez C, Johnson T, Rolston K, Merriman K, Warneke C, Evans S. Predicting pneumonia mortality using CURB-65, PSI, and patient characteristics in patients presenting to the emergency department of a comprehensive cancer center. Cancer Med. 2014;3(4):962–70.	en
dcterms.references	Macfarlane J, Boswell T DG. BTS guidelines for management of communityacquired pneumonia in adults—2004 update. Br Thorac Soc. 2004;59(5):361–3.	en
dcterms.references	Buising KL, Thursky KA, Black JF, Macgregor L, Street AC, Marcus P. Identifying severe community-acquired pneumonia in the emergency department : A simple clinical prediction tool Objective : Methods : Results : Conclusion : Emerg Med Australas. 2007;18:418–26.	en
dcterms.references	Charles PGP, Wolfe R, Whitby M, Fine MJ, Fuller AJ, Stirling R, et al. SMART‐COP: A Tool for Predicting the Need for Intensive Respiratory or Vasopressor Support in Community‐Acquired Pneumonia. Clin Infect Dis. 2008;47(3):375–84	en
dcterms.references	Woodhead M, Blasi F, Ewig S, Garau J, Huchon G, Ieven M, et al. Guidelines for the management of adult lower respiratory tract infections - Full version. Clin Microbiol Infect [Internet]. 2011;17:E1–59. Available from: http://dx.doi.org/10.1111/j.1469-0691.2011.03672.x	en
dcterms.references	File TM, Marrie TJ. Burden of community-acquired pneumonia in North American adults. Postgrad Med. 2010;122(2):130–41.	en
dcterms.references	Jordi Carratalá, Núria Fernandez-Sabe, Lucia Ortega, Xavier Castellsagué, Beatriz Rosón, Jordi Dorca AFA. Outpatient Care Compared with Hospitalization for. Ann Intern Med. 2005;142:165–72	en
dcterms.references	McNally M, Curtain J, O’Brien KK, Dimitrov BD, Fahey T. Validity of British Thoracic Society guidance (the CRB-65 rule) for predicting the severity of pneumonia in general practice: Systematic review and meta-analysis. Br J Gen Pract. 2010;60(579):423–33.	en
dcterms.references	Bauer TT, Ewig S, Marre R, Suttorp N, Welte T. CRB-65 predicts death from community-acquired pneumonia. J Intern Med. 2006;260(1):93–101.	en
dcterms.references	Mandell LA, Marrie TJ, Grossman RF, Chow AW, Hyland RH. Summary of Canadian guidelines for the initial management of community-acquired pneumonia: An evidence-based update by the Canadian infectious disease society and the Canadian thoracic society. Can Respir J. 2000;7(5):371–82.	en
dcterms.references	Choudhury G, Chalmers JD, Mandal P, Akram AR, Murray MP, Short P, et al. Physician judgement is a crucial adjunct to pneumonia severity scores in low-risk patients. Eur Respir J. 2011;38(3):643–8.	en
dcterms.references	Chalmers JD, Singanayagam A, Akram AR, Mandal P, Short PM, Choudhury G, et al. Severity assessment tools for predicting mortality in hospitalised patients with community-acquired pneumonia. Systematic review and metaanalysis. Thorax. 2010;65(10):878–83.	en
dcterms.references	Loke YK, Kwok CS, Niruban A, Myint PK. Value of severity scales in predicting mortality from community-acquired pneumonia: Systematic review and meta-analysis. Thorax. 2010;65(10):884–90.	en
dcterms.references	Akram AR, Chalmers JD, Hill AT. Predicting mortality with severity assessment tools in out-patients with community-acquired pneumonia. Qjm. 2011;104(10):871–9.	en
dcterms.references	Majumdar SR, Eurich DT, Gamble JM, Senthilselvan A, Marrie TJ. Oxygen saturations less than 92% are associated with major adverse events in outpatients with pneumonia: A population-based cohort study. Clin Infect Dis. 2011;52(3):325–31	en
dcterms.references	Halm EA, Atlas SJ, Borowsky LH, Benzer TI, Metlay JP, Chang Y, et al. Understanding Physician Adherence With a Pneumonia Practice Guideline. Arch Intern Med. 2000;160(1):98.	en
dcterms.references	Chalmers JD, Taylor JK, Singanayagam A, Fleming GB, Akram AR, Mandal P, et al. Epidemiology, antibiotic therapy, and clinical outcomes in health care-associated pneumonia: A UK cohort study. Clin Infect Dis. 2011;53(2):107–13.	en
dcterms.references	Kolditz M, Ewig S, Schütte H, Suttorp N, Welte T, Rohde G. Assessment of oxygenation and comorbidities improves outcome prediction in patients with community-acquired pneumonia with a low CRB-65 score. J Intern Med. 2015;278(2):193–202.	en
dcterms.references	Dwyer R, Hedlund J, Henriques-Normark B, Kalin M. Improvement of CRB65 as a prognostic tool in adult patients with community-acquired pneumonia. BMJ Open Respir Res. 2014;1(1):1–7.	en
dcterms.references	Corrales-Medina VF, Musher DM, Wells GA, Chirinos JA, Chen L, Fine MJ. Cardiac complications in patients with community-acquired pneumonia incidence, timing, risk factors, and association with short-term mortality. Circulation. 2012;125(6):773–81.	en
dcterms.references	Aliberti S, Ramirez J, Cosentini R, Valenti V, Voza A, Rossi P, et al. Acute myocardial infarction versus other cardiovascular events in communityacquired pneumonia. ERJ Open Res [Internet]. 2015;1(1):1–9. Available from: http://dx.doi.org/10.1183/23120541.00020-2015	en
dcterms.references	Dwyer R, Hedlund J, Darenberg J, Henriques-Normark B, Naucler P, Runesdotter S, et al. Improvement of CRB-65 as a prognostic scoring system in adult patients with bacteraemic pneumococcal pneumonia. Scand J Infect Dis. 2011;43(6–7):448–55.	en
dcterms.references	Welte T, Torres A, Nathwani D. Clinical and economic burden of communityacquired pneumonia among adults in Europe. Thorax. 2012;67(1):71–	en
dcterms.references	Bartlett JG ML. Current concepts community-acquired pneumonia. N Engl J Med. 1995;222:1618–24.	en
dcterms.references	Saldías Peñafiel F, O’Brien Solar A, Gederlini Gollerino A, Farías Gontupil G, Díaz Fuenzalida A. Neumonía adquirida en la comunidad en el anciano inmunocompetente que requiere hospitalización. Cuadro clínico, factores 60 pronósticos y tratamiento. Arch Bronconeumol. 2003;39(8):333–40.	es_CO
dcterms.references	Potgieter PD, Hammond JMJ. The intensive care management, mortality and prognostic indicators in severe community-acquired pneumococcal pneumonia. Intensive Care Med. 1996;22(12):1301–6.	en
dcterms.references	Lee JH, Kim J, Kim K, Jo YH, Rhee JE, Kim TY, et al. Albumin and Creactive protein have prognostic significance in patients with communityacquired pneumonia. J Crit Care [Internet]. 2011;26(3):287–94. Available from: http://dx.doi.org/10.1016/j.jcrc.2010.10.007	en
dcterms.references	Ugajin M, Yamaki K, Iwamura N, Yagi T, Asano T. Blood urea nitrogen to serum albumin ratio independently predicts mortality and severity of community-acquired pneumonia. Int J Gen Med. 2012;5:583–9.	en
dcterms.references	Akpinar EE, Hosgun D DB et al. The role of albumin level and blood urea nitrogen/albumin ratio in prediction of prognosis of community acquired pneumonia. J Pulm Respir Med [Internet]. 2013;3(2):4–8. Available from: http://dx.doi.org/10.4172/2161-105X.	en
dcterms.references	Tokgoz Akyil F, Yalcinsoy M, Hazar A, Cilli A, Celenk B, Kilic O, et al. Prognosis of hospitalized patients with community-acquired pneumonia. Rev Port Pneumol (English Ed [Internet]. 2018;24(3):164–9. Available from: http://dx.doi.org/10.1016/j.rppnen.2017.07.010	en
dcterms.references	Potter VAJ. Pulse oximetry in general practice: How would a pulse oximeter influence patient management? Eur J Gen Pract. 2007;13(4):216–20.	en
dcterms.references	Strålin K, Holmberg H, Mortensen E, Obrosky DS, Fine MJ. Causes of death for patients with community-acquired pneumonia [3] (multiple letters). Arch Intern Med. 2002;162(21):2491–3.	en
dcterms.references	España PP, Capelastegui A, Gorordo I, Esteban C, Oribe M, Ortega M, et al. Development and validation of a clinical prediction rule for severe community-acquired pneumonia. Am J Respir Crit Care Med. 2006;174(11):1249–56.	en
dcterms.references	Wu CL, Lin FJ, Lee SY, Lee CH, Peng MJ, Chen PJ, et al. Early evolution of arterial oxygenation in severe community-acquired pneumonia: A prospective observational study. J Crit Care. 2007;22(2):129–36	en
dcterms.references	1. Sanz F, Restrepo MI, Fernández E, Briones ML, Blanquer R, Mortensen EM, et al. Is it possible to predict which patients with mild pneumonias will develop hypoxemia? Respir Med. 2009;103(12):1871–7.	en
dcterms.references	Mower WR, Sachs C, Nicklin EL, Safa P, Baraff LJ. Effect of routine emergency department triage pulse oximetry screening on medical management. Chest [Internet]. 1995;108(5):1297–302. Available from: http://dx.doi.org/10.1378/chest.108.5.1297	en
dcterms.references	Blot SI, Rodriguez A, Solé-Violán J, Blanquer J, Almirall J, Rello J. Effects of delayed oxygenation assessment on time to antibiotic delivery and mortality in patients with severe community-acquired pneumonia. Crit Care Med. 2007;35(11):2509–14.	en
dcterms.references	Ewig S, Ruiz M, Mensa J, Marcos MA, Martinez JA, Arancibia F, et al.	en
dcterms.references	Myint PK, Kamath A V., Vowler SL, Maisey DN, Harrison BDW. Severity assessment criteria recommended by the British Thoracic Society (BTS) for community-acquired pneumonia (CAP) and older patients. Should SOAR (systolic blood pressure, oxygenation, age and respiratory rate) criteria be used in older people? A comp. Age Ageing. 2006;35(3):286–91.	en
dcterms.references	Subramanian DN, Musonda P, Sankaran P, Tariq SM, Kamath A V., Myint PK. Performance of SOAR (systolic blood pressure, oxygenation, age and respiratory rate) scoring criteria in community-acquired pneumonia: A prospective multi-centre study. Age Ageing. 2013;42(1):94–7.	en
dcterms.references	Williams E, Girdwood J, Janus E, Karunajeewa H. CORB is the best pneumonia severity score for elderly hospitalised patients with suspected pneumonia. Intern Med J. 2014;44(66):613–5.	en
dcterms.references	Martínez GM , Casas DP, Bastidas AR, Oliveros H, Pinilla PA, Calderón WJ CF. Oxygen indexes as predictors of mechanical ventilation in pneumonia at 2600 meters above sea level. Acta Medica Colomb. 2016;41(3):169–75.	en
dcterms.references	Lynch JP, Sitrin RG. Noninfectious mimics of community-acquired pneumonia. Semin Respir Infect [Internet]. 1993;8(1):14–45. Available from: http://dx.doi.org/10.1186/s41479-016-0002-1	en
dcterms.references	Garcia-Vidal C, Fernández-Sabé N, Carratalà J, Díaz V, Verdaguer R, Dorca J, et al. Early mortality in patients with community-acquired pneumonia: Causes and risk factors. Eur Respir J. 2008;32(3):733–9.	en
dcterms.references	Lanks CW, Musani AI, Hsia DW. Community-acquired Pneumonia and Hospital-acquired Pneumonia. Med Clin North Am [Internet]. 2019;103(3):487–501. Available from: https://doi.org/10.1016/j.mcna.2018.12.008	en
dcterms.references	Kwack WG, Lee DS, Min H, Choi YY, Yun M, Kim Y, et al. Evaluation of the SpO2/FiO2 ratio as a predictor of intensive care unit transfers in respiratory ward patients for whom the rapid response system has been activated. PLoS One. 2018;13(7):1–11	en
dcterms.references	Roca O, Messika J, Caralt B, García-de-Acilu M, Sztrymf B, Ricard JD, et al. Predicting success of high-flow nasal cannula in pneumonia patients with hypoxemic respiratory failure: The utility of the ROX index. J Crit Care [Internet]. 2016;35:200–5. Available from: http://dx.doi.org/10.1016/j.jcrc.2016.05.022	en
dcterms.references	Bernard GR, Artigas A, Brigham KL, Carlet J, Falke K, Hudson L, et al. Definitions , Mechanisms , Relevant Outcomes , and Clinical Trial Coordination. Crit Care Med. 1994;149:818–24.	en
dcterms.references	Luna CM, Blanzaco D, Niederman MS, Matarucco W, Baredes NC, Desmery P, et al. Resolution of ventilator-associated pneumonia: Prospective evaluation of the clinical pulmonary infection score as an early clinical predictor of outcome. Crit Care Med. 2003;31(3):676–82.	en
dcterms.references	Williams JM, Greenslade JH, Chu KH, Brown AFT, Lipman J. Utility of community-acquired pneumonia severity scores in guiding disposition from the emergency department: Intensive care or short-stay unit? EMA - Emerg Med Australas. 2018;30(4):538–46.	en
dcterms.references	Rice TW, Wheeler AP, Bernard GR, Hayden DL, Schoenfeld DA, Ware LB. Comparison of the SpO2/FIO2 ratio and the PaO 2/FIO2 ratio in patients with acute lung injury or ARDS. Chest. 2007;132(2):410–7.	en
thesis.degree.discipline	Facultad de Medicina	es_CO
thesis.degree.level	Especialización en Medicina Interna	es_CO
thesis.degree.name	Especialista en Medicina Interna	es_CO