@article{10818/33130,
year = {2017},
month = {5},
url = {http://hdl.handle.net/10818/33130},
abstract = {It was purposed to evaluate the biological potential of ethanol and isopropanol crude extracts of ripe Physalis peruviana fruits.
Cytotoxic and immunomodulatory effects of the expression of interleukin-6, interleukin-8, and monocyte chemoattractant
protein-1 (MCP-1) were evaluated on human cervical cancer (HeLa) and murine fibroblast (L929) cells. The composition was
evaluated by high-performance liquid chromatography diode-array detection and high-performance liquid chromatography
ultraviolet/visible detection. The presence of ursolic acid and rosmarinic acid was found in both solvents. However, gallic acid,
quercetin, and epicatechin were higher in isopropanol extracts (P < .05). The results indicated a relationship among the total
polyphenol content, antioxidant activity, and cytotoxic activity that was dependent on the solvent used. Isopropanol extracts
presented a half-maximal inhibition concentration value (IC50) of 60.48 + 3.8 mg/mL for HeLa cells and 66.62 + 2.67 mg/mL for
L929 fibroblasts. The extracts reduced the release of interleukin-6, interleukin-8, and MCP-1 in a dose-dependent manner.
Extracts showed anticancer and immunomodulatory potential for new complementary pharmaceutical products development.},
publisher = {Journal of Evidence-Based Complementary & Alternative Medicine},
keywords = {Cytotoxicity},
keywords = {Immunomodulatory},
keywords = {Antioxidants},
title = {Cytotoxic and Immunomodulatory Potential Activity of Physalis peruviana Fruit Extracts on Cervical Cancer (HeLa) and Fibroblast (L929) Cells},
doi = {10.1177/2156587217718751},
author = {Mier Giraldo, Helen and Díaz Barrera, Luis Eduardo and Delgado Murcia, Lucy Gabriela and Valero Valdivieso, Manuel Fernando and Cáez Ramírez, Gabriela Rabe},
}